: From Multidrug Resistance to Pan-Resistant Strains.

is an emerging multidrug-resistant fungus that is rapidly spreading worldwide. Currently, cases have been reported globally from >30 countries. Most reported infections involve critically ill patients in hospitals, mainly in intensive care unit settings. Infection with is associated with high mortality rates, and it is often resistant to multiple classes of antifungal drugs. Despite the rapid global spread, it is difficult to predict the actual burden of the infection as the standard laboratory methods fail to correctly identify the fungi. Longer stays in healthcare facilities, use of tracheostomies and percutaneous endoscopic gastrostomy tubes, ventilators in clinical care units and mobile equipment in healthcare settings are shown as major risk factors of infection. Due to its propensity to cause outbreaks and its antifungal resistance, poses a risk for patients in healthcare facilities. The emergence of pan-resistant strains in some areas is an alarming signal for the disease with limited treatment options, high mortality rates, and the ability of the pathogen to spread easily in healthcare settings. In this regard, susceptibility testing on clinical isolates, mainly for patients treated with echinocandins, is needed. Increasing awareness about infection and advancing the diagnostic methods are also essential for early detection and control of the deadly fungal infection.