Iannone Michela, Salvia Giorgia, Fidanzi Cristian, Bevilacqua Matteo, Janowska Agata, Morganti Riccardo, Romanelli Marco, Dini Valentina
Department of Dermatology, University of Pisa, Pisa, Italy.
Department of Clinical and Experimental Medicine, Section of Statistics, University of Pisa, Pisa, Italy.
Skin Appendage Disord. 2023 Jun;9(3):165-168. doi: 10.1159/000528658. Epub 2023 Feb 20.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with systemic inflammation and high impact on quality of life. Treatment strategies are still inadequate with a lack of inflammation biomarkers. We conducted a prospective study to assess the correlation between serum amyloid A (SAA) levels and active lesion count; disease severity; Dermatology Life Quality Index (DLQI); smoking; BMI; and lesion sites.
Forty-one patients (M/F: 22/19) were enrolled. Demographic, clinical, laboratory, and therapeutic data were assessed at baseline on patients not under treatment or in wash-out from systemic treatment for at least 2 weeks. Associations were investigated by univariate and multivariate analyses.
SAA levels were significantly associated with number of nodules ( = 0.005), abscesses ( < 0.001), fistulas ( = 0.016), and severe IHS4 ( = 0.088 and = 0.514). Gluteal localization was correlated with high values of mSartorius and severe IHS4.
We recommend assessment of SAA levels to monitor therapeutic response in patient with HS in order to prevent disease's flare and potential complications.
化脓性汗腺炎（HS）是一种慢性炎症性皮肤病，伴有全身炎症，对生活质量有很大影响。由于缺乏炎症生物标志物，治疗策略仍然不足。我们进行了一项前瞻性研究，以评估血清淀粉样蛋白A（SAA）水平与活动性皮损计数、疾病严重程度、皮肤病生活质量指数（DLQI）、吸烟、体重指数（BMI）以及皮损部位之间的相关性。
纳入41例患者（男/女：22/19）。对未接受治疗或已停用全身治疗至少2周的患者在基线时评估其人口统计学、临床、实验室和治疗数据。通过单变量和多变量分析研究相关性。
SAA水平与结节数量（P = 0.005）、脓肿数量（P < 0.001）、瘘管数量（P = 0.016）以及严重IHS4（P = 0.088和P = 0.514）显著相关。臀部分布与缝匠肌高值和严重IHS4相关。
我们建议评估SAA水平，以监测HS患者的治疗反应，从而预防疾病复发和潜在并发症。
