Liakou Aikaterini I, Rotsiamis Nikolaos, Tsantes Andreas G, Routsi Eleni, Rompoti Natalia, Ioannou Petros, Mpakosi Alexandra, Tsamtsouri Lydia, Agiasofitou Efthymia, Kotsafti Ourania, Bonovas Stefanos, Katoulis Alexander, Papadavid Evangelia, Rigopoulos Dimitris
1st Department of Dermatology-Venereology, "Andreas Sygros" Hospital, Medical School, National and Kapodistrian University of Athens, 16121 Athens, Greece.
2nd Department of Dermatology-Venereology, "Attikon" University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
J Clin Med. 2024 Sep 28;13(19):5795. doi: 10.3390/jcm13195795.
: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder with a significant impact on the quality of life of affected patients. This study aimed to correlate serum inflammatory markers with specific tools assessing quality of life, emotional well-being, and loneliness, such as the Dermatology Life Quality Index (DLQI), Hospital Anxiety and Depression Scale (HADS), and the UCLA Loneliness Scale. : A pilot observational study including 37 patients with HS was conducted. Inflammatory serum markers, including C-reactive protein (CRP) and Erythrocyte Sedimentation Rate (ESR), were evaluated at baseline, 3 months, and 6 months later. Psychometric scores were also evaluated at the same study intervals. : DLQI was correlated with ESR at baseline (Spearman's rho = 0.35, = 0.03), indicating that poorer quality of life is associated with changes in this serum marker. Disease activity, as reflected by inflammatory markers, was associated with significant psychological burden. Specifically, a worse DLQI score was associated with higher ESR (estimate β = 0.14, 95% confidence interval [CI]: 0.05-0.22; = 0.001) and higher CRP level (estimate β = 0.25, 95% CI: 0.02-0.48; = 0.02). Similarly, a worse UCLA score was associated with higher ESR (estimate β = 0.11, 95% CI: 0.02-0.20, = 0.01). : Our study results underline the close relation between systemic inflammatory markers and clinical severity together with psychological burden in HS patients, as indicated by the significant association that was revealed between ESR/CRP and poorer psychometric scores. However, further research is warranted to validate these findings.
化脓性汗腺炎（HS）是一种慢性炎症性皮肤病，对受影响患者的生活质量有重大影响。本研究旨在将血清炎症标志物与评估生活质量、情绪健康和孤独感的特定工具相关联，如皮肤病生活质量指数（DLQI）、医院焦虑抑郁量表（HADS）和加州大学洛杉矶分校孤独量表。：开展了一项纳入37例HS患者的初步观察性研究。在基线、3个月和6个月后评估包括C反应蛋白（CRP）和红细胞沉降率（ESR）在内的炎症血清标志物。在相同的研究间隔也评估心理测量分数。：DLQI在基线时与ESR相关（斯皮尔曼等级相关系数rho = 0.35，P = 0.03），表明较差的生活质量与该血清标志物的变化相关。炎症标志物所反映的疾病活动与显著的心理负担相关。具体而言，较差的DLQI评分与较高的ESR（估计β = 0.14，95%置信区间[CI]：0.05 - 0.22；P = 0.001）和较高的CRP水平（估计β = 0.25，95% CI：0.02 - 0.48；P = 0.02）相关。同样，较差的加州大学洛杉矶分校孤独量表评分与较高的ESR相关（估计β = 0.11，95% CI：0.02 - 0.20，P = 0.01）。：我们的研究结果强调了系统性炎症标志物与HS患者临床严重程度以及心理负担之间的密切关系，ESR/CRP与较差的心理测量分数之间存在显著关联即表明了这一点。然而，需要进一步研究来验证这些发现。
