College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China.
Laoshan Laboratory, Qingdao 266237, P. R. China.
J Mater Chem B. 2023 Jul 19;11(28):6478-6490. doi: 10.1039/d3tb00839h.
High temperature generated by photothermal therapy (PTT) can trigger an inflammatory response at the tumor site, which not only limits the efficacy of PTT but also increases the risk of tumor metastasis and recurrence. In light of the current limitations posed by inflammation in PTT, several studies have revealed that inhibiting PTT-induced inflammation can significantly improve the efficacy of cancer treatment. In this review, we summarize the research progress made in combining anti-inflammatory strategies to enhance the effectiveness of PTT. The goal is to offer valuable insights for developing better-designed photothermal agents in clinical cancer therapy.
光热疗法(PTT)产生的高温会在肿瘤部位引发炎症反应,这不仅限制了 PTT 的疗效,还增加了肿瘤转移和复发的风险。鉴于 PTT 中炎症带来的当前局限性,多项研究表明,抑制 PTT 诱导的炎症反应可以显著提高癌症治疗的效果。在本综述中,我们总结了结合抗炎策略来增强 PTT 效果的研究进展。旨在为开发用于临床癌症治疗的设计更好的光热剂提供有价值的见解。