Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, Hubei University, Wuhan 430062, China.
Glyn O. Philips Hydrocolloid Research Centre at HUT, Hubei University of Technology, Wuhan, Hubei 430068, China.
Acta Biomater. 2023 Mar 15;159:312-323. doi: 10.1016/j.actbio.2023.01.049. Epub 2023 Jan 25.
As a controllable, simple method with few side effects, near-infrared (NIR) light-based photothermal therapy (PTT) has been proven an effective cancer therapeutic approach. However, PTT-induced inflammation is a potential negative factor. And the overexpressed heat shock proteins (HSPs) by cancer cells can protect them from hyperthermia during PTT. In this work, small-size TiCT MXene nanosheets with high photothermal conversion efficiency in the region of NIR, high cargo loading capability and good free radical scavenging capability were chosen for cancer PTT and anti-inflammation. And (-)-epigallocatechin gallate (EGCG) was applied to form EGCG/Fe metal-polyphenol nanodots on the nanosheets. EGCG being released in acid cancer cells could reduce the expression of HSPs and could be used for anti-inflammation. As a result, the complex nanosheets named MXene@EGCG could achieve enhanced cancer PTT and be anti-inflammatory. Both in vitro and in vivo studies proved the good photothermal ability of MXene@EGCG and demonstrated that it could inhibit the expression of HSPs in tumor cells and relieve PTT-induced inflammation. Therefore, the nanosheets show good results in tumor ablation with a low level of inflammation, which provides another possibility for cancer therapy. STATEMENT OF SIGNIFICANCE: Photothermal therapy (PTT)-induced inflammation plays an essential role in some important stages of tumor development and is unfavorable for cancer treatment. And hyperthermia leads to the overexpression of heat shock proteins (HSPs) in cancer cells, which limits the therapeutic effect of PTT. Therefore, we coated small-size TiCT MXene nanosheets with (-)-epigallocatechin gallate (EGCG)/Fe metal-polyphenol nanodots and named them as MXene@EGCG. This system shows a good photothermal conversion efficiency at 808 nm. And it can release EGCG in cancer cells to inhibit the expression of HSPs, thus achieving an enhanced cancer PTT. Both MXene and EGCG can also diminish the PTT-trigged inflammation. Both in vitro and in vivo studies prove the good anti-cancer PTT effect and anti-inflammation capability of MXene@EGCG.
作为一种可控、简单且副作用少的方法，近红外（NIR）光热疗法（PTT）已被证明是一种有效的癌症治疗方法。然而，PTT 诱导的炎症是一个潜在的负面因素。并且癌细胞中过度表达的热休克蛋白（HSPs）可以在 PTT 期间保护它们免受高热。在这项工作中，选择了具有高光热转换效率（在 NIR 区域）、高载药能力和良好自由基清除能力的小尺寸 TiCT MXene 纳米片用于癌症 PTT 和抗炎。并且将（-）-表没食子儿茶素没食子酸酯（EGCG）应用于纳米片上形成 EGCG/Fe 金属多酚纳米点。在酸性癌细胞中释放的 EGCG 可以降低 HSPs 的表达，可用于抗炎。结果，将这种复合纳米片命名为 MXene@EGCG，可以实现增强的癌症 PTT 并具有抗炎作用。体外和体内研究均证明了 MXene@EGCG 的良好光热性能，并表明它可以抑制肿瘤细胞中 HSPs 的表达并缓解 PTT 诱导的炎症。因此，该纳米片在低炎症水平下显示出良好的肿瘤消融效果，为癌症治疗提供了另一种可能。
意义声明：光热疗法（PTT）诱导的炎症在肿瘤发展的一些重要阶段起着重要作用，不利于癌症治疗。并且，热疗会导致癌细胞中热休克蛋白（HSPs）的过度表达，从而限制了 PTT 的治疗效果。因此，我们在小尺寸 TiCT MXene 纳米片上包覆（-）-表没食子儿茶素没食子酸酯（EGCG）/Fe 金属多酚纳米点，并将其命名为 MXene@EGCG。该系统在 808nm 处表现出良好的光热转换效率。并且它可以在癌细胞中释放 EGCG 以抑制 HSPs 的表达，从而实现增强的癌症 PTT。MXene 和 EGCG 都可以减轻 PTT 触发的炎症。体外和体内研究均证明了 MXene@EGCG 的良好抗癌 PTT 效果和抗炎能力。
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