Maternity School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Professional Master Perinatal Health, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Maternity School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Clinical Medicine Postgraduate Program, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Pregnancy Hypertens. 2023 Sep;33:17-21. doi: 10.1016/j.preghy.2023.06.001. Epub 2023 Jun 14.
To evaluate the prevalence and perinatal repercussions of preeclampsia (PE) after the implementation of a prophylaxis protocol with aspirin in singleton pregnancy at Maternity School of Federal University of Rio de Janeiro, Rio de Janeiro, Brazil (2015-2106).
PE prevalence according to gestational age (GA) and the prevalence ratio (PR) between PE and prematurity, small for gestational age (SGA), and fetal death were calculated in patients assisted during 2015 and 2016.
PE occurred in 373(10.75%) of 3468 investigated cases, where PE < 37 weeks was of 2.79% and PE greater than 37 weeks was of 7.95%. A total of 413 (11.9%) prematurity cases, 320 SGA (9.22%), and 50 fetal deaths (1.44%) occurred. In the PE group, 97 premature newborns (PR 0.90) and 51 SGA (PR 1.16) were born, and two fetal deaths occurred (PR 7.46). Concerning PE < 37 weeks, 27 SGA cases (PR 1.42) and two fetal deaths (PR 2.62) were observed. Regarding PE greater than 37 weeks, 24 SGA (PR 1.09) were born, and no fetal deaths were observed. Our findings were compared to previously published results.
PE was significantly associated with SGA newborns, especially premature PE. Prescribing aspirin for PE prophylaxis based only on clinical risk factors in a real-life scenario does not appear to be effective but resulted in a PE screening and prophylaxis protocol review and update at ME/UFRJ.
评估巴西里约热内卢联邦大学妇产学校（2015-2016 年）实施阿司匹林预防单胎妊娠子痫前期（PE）方案后的患病率及其围产期影响。
计算 2015 年和 2016 年就诊患者的 PE 按孕龄（GA）的患病率和 PE 与早产、小于胎龄儿（SGA）和胎儿死亡的患病率比（PR）。
3468 例患者中，PE 发生 373 例（10.75%），其中<37 周 PE 为 2.79%，>37 周 PE 为 7.95%。共有 413 例（11.9%）早产，320 例 SGA（9.22%）和 50 例胎儿死亡（1.44%）。PE 组有 97 例早产新生儿（PR 0.90）和 51 例 SGA（PR 1.16），2 例胎儿死亡（PR 7.46）。对于<37 周的 PE，观察到 27 例 SGA（PR 1.42）和 2 例胎儿死亡（PR 2.62）。对于>37 周的 PE，有 24 例 SGA（PR 1.09）出生，无胎儿死亡。我们的发现与以前发表的结果进行了比较。
PE 与 SGA 新生儿显著相关，尤其是早产 PE。在实际情况下，仅基于临床危险因素开具阿司匹林预防 PE 的处方似乎并不有效，但导致 ME/UFRJ 审查和更新了 PE 筛查和预防方案。
