Nikonenko B V, Apt A S, Moroz A M, Averbakh M M
Genetika. 1986 May;22(5):851-4.
Susceptibility of inbred mouse strains, their F1 hybrids, offsprings from BC1 and RI strains from CXB pannel to tuberculosis infection was studied. Mice were infected with virulent strain of M. tuberculosis H37Rv. All F1 hybrids, with the exception of (BRSUNT X I/St)F1, showed superresistance, due apparently to heterosis effect; (BRSUNT X I/St)F1 demonstrated an intermediate level of resistance, as compared with parental strains. Analysis of [(BALB/c X B6)F1 X B6]BC1, [(BALB/c X B6)F1 X BALB/c]BC1 offsprings and RI strains indicated that strains BALB/c and B6 have different alleles of at least two genetic loci mediating susceptibility to tuberculosis.
研究了近交系小鼠品系、它们的F1杂种、来自CXB面板的BC1和RI品系的后代对结核感染的易感性。小鼠用结核分枝杆菌H37Rv的强毒株感染。所有F1杂种，除了（BRSUNT×I/St）F1外，均表现出超抗性，这显然归因于杂种优势效应；与亲本品系相比，（BRSUNT×I/St）F1表现出中等水平的抗性。对[（BALB/c×B6）F1×B6]BC1、[（BALB/c×B6）F1×BALB/c]BC1后代和RI品系的分析表明，BALB/c和B6品系至少有两个介导结核易感性的基因座具有不同的等位基因。
