Nikonenko B V, Apt A S, Mezhlumova M B, Moroz A M
Genetika. 1990 Dec;26(12):2254-7.
The relationship of the mouse Bcg and Tbc-1 genes was studied. It was shown that the F1 hybrids between highly susceptible to tuberculosis mice I/St (Tbc-1s) and the Bcgs-carrying strains were highly resistant to M. tuberculosis H37Rv infection. These results point to complementation of Bcgs and Tbc-1s genes. Analysis of survival time of the [(AKR x B10-fzy)F1 x B10-Fzy]BC1 offspring showed that the mouse chromosome 1 does not regulate resistance to H37Rv infection. No linkage of the Tbc-1s gene with chromosome 1 was revealed when using fzy gene as a marker of the chromosome 1.
对小鼠Bcg和Tbc-1基因的关系进行了研究。结果表明，对结核病高度易感的I/St小鼠（Tbc-1s）与携带Bcgs的品系之间的F1杂种对结核分枝杆菌H37Rv感染具有高度抗性。这些结果表明Bcgs和Tbc-1s基因存在互补作用。对[(AKR×B10-fzy)F1×B10-Fzy]BC1后代存活时间的分析表明，小鼠1号染色体不调控对H37Rv感染的抗性。当使用fzy基因作为1号染色体的标记时，未发现Tbc-1s基因与1号染色体存在连锁关系。
