抗阻训练对成年人肌肉生长抑制素和激活素的影响：系统评价和荟萃分析。

The effects of resistance training on myostatin and follistatin in adults: A systematic review and meta-analysis.

机构信息

Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran.

Department of Physical Education and Sports Science, School of Psychology and Educational Sciences, Yazd University, Yazd, Iran.

出版信息

Physiol Behav. 2023 Oct 1;269:114272. doi: 10.1016/j.physbeh.2023.114272. Epub 2023 Jun 14.

DOI:10.1016/j.physbeh.2023.114272

PMID:37328021

Abstract

INTRODUCTION AND AIM

Myostatin and follistatin are the main hormones for regulating muscle mass, and previous research suggests they are modulated by resistance training. We therefore performed a systematic review and meta-analysis to investigate the impact of resistance training on circulating myostatin and follistatin in adults.

METHODS

A search was conducted in PubMed and Web of science from inception until October 2022 to identify original studies investigating the effects of resistance training compared with controls that did not exercise. Standardized mean differences and 95% confidence intervals (CIs) were calculated using random effects models.

RESULTS

A total 26 randomized studies, including 36 interventions, and involving 768 participants (aged ∼18 - 82 years), were included in the meta-analysis. Resistance training effectively decreased myostatin [-1.31 (95% CI -1.74 - -0.88, p = 0.001, 26 studies] and increased follistatin [2.04 (95% CI: 1.51 - 2.52), p = 0.001, 14 studies]. Subgroup analyses revealed a significant decrease in myostatin and increase in follistatin regardless of age.

CONCLUSION

Resistance training in adults is effective for reducing myostatin and increasing follistatin which may contribute to the beneficial effects of resistance training on muscle mass and metabolic outcomes.

摘要

简介和目的

肌肉生长抑制素和激活素是调节肌肉量的主要激素，先前的研究表明它们受到抗阻训练的调节。因此，我们进行了系统评价和荟萃分析，以研究抗阻训练对成年人循环中肌肉生长抑制素和激活素的影响。

方法

从建库到 2022 年 10 月，在 PubMed 和 Web of Science 中进行了检索，以确定调查抗阻训练与未运动对照组之间影响的原始研究。使用随机效应模型计算标准化均数差值和 95%置信区间（CI）。

结果

共有 26 项随机研究，包括 36 项干预措施，涉及 768 名参与者（年龄约为 18-82 岁），纳入荟萃分析。抗阻训练可有效降低肌肉生长抑制素[-1.31（95%CI -1.74 - -0.88，p = 0.001，26 项研究]和增加激活素[2.04（95%CI：1.51 - 2.52），p = 0.001，14 项研究]。亚组分析显示，无论年龄大小，肌肉生长抑制素降低和激活素增加均具有显著意义。