Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Int J Obes (Lond). 2024 Dec;48(12):1803-1808. doi: 10.1038/s41366-024-01630-3. Epub 2024 Sep 16.
Traditional forms of exercise affect immune, metabolic, and myokine responses and contribute to a multitude of health benefits. Whole body vibration (WBV) has recently emerged as an exercise mimetic that may be more tolerable for those individuals that cannot perform traditional exercise. However, the myokines response to acute WBV in humans has yet to be fully elucidated.
To characterize the decorin and myostatin response to acute whole body vibration (WBV) and determine the impact of adiposity, sex, and race.
One hundred twenty-nine adults (32.8 ± 0.4 years, 66.7% female, 53.5% non-Hispanic Black) were recruited as part of an ongoing, longitudinal twin cohort parent study. Participants were classified into three groups: those with obesity (OB: ≥30 kg/m), those who are overweight (OW: ≥25 and <30 kg/m), or those with normal weight (NW: <25 kg/m) based on BMI.
Blood was collected at baseline (PRE), immediately post (POST), and 1 h (1H), 3 h (3H), and 24 h (24H) post WBV. The acute WBV protocol consisted of 10 cycles of 1 min of vibration exercise followed by 30 s of standing rest.
The response was similar between NW and OW, so these groups were combined for analysis (NW/OW: BMI < 30 kg/m). Overall, circulating concentrations of decorin were higher (p < 0.001) POST (8.80 ± 0.19 pg/mL) and significantly lower (p's ≤ 0.005) at 1H (8.66 ± 0.19 pg/mL) and 3H (8.68 ± 0.19 pg/mL), compared to PRE (8.71 ± 0.19 pg/mL). Decorin POST was greater (p = 0.016) in the OB group (8.82 ± 0.18 pg/mL) compared to the NW/OW group (8.77 ± 0.20 pg/mL). Overall, myostatin was higher (p = 0.002) POST (54.93 ± 1.04 pg/mL) and lower (p < 0.001) at 24H (49.13 ± 1.04 pg/mL) compared to PRE (53.49 ± 1.04 pg/mL). The myostatin response was lower (p's ≤ 0.001) in female and non-Hispanic White individuals compared to male and non-Hispanic Black individuals, respectively.
A single bout of WBV can facilitate the release of decorin and myostatin into circulation, a similar response to traditional exercise. Additionally, adiposity, sex and race should be considered when evaluating the myokines response to WBV.
传统形式的运动影响免疫、代谢和肌肉因子反应，并有助于多种健康益处。全身振动（WBV）最近作为一种运动模拟物出现，对于那些无法进行传统运动的人来说可能更耐受。然而，人体对急性全身振动的肌肉因子反应尚未完全阐明。
描述急性全身振动（WBV）对核心蛋白聚糖和肌肉生长抑制素的反应，并确定肥胖、性别和种族的影响。
129 名成年人（32.8±0.4 岁，66.7%为女性，53.5%为非西班牙裔黑人）作为正在进行的纵向双胞胎队列父母研究的一部分被招募。参与者根据 BMI 分为三组：肥胖组（OB：≥30kg/m）、超重组（OW：≥25 且 <30kg/m）或正常体重组（NW：<25kg/m）。
在 WBV 之前（PRE）、之后立即（POST）以及 1 小时（1H）、3 小时（3H）和 24 小时（24H）采集血液。急性 WBV 方案包括 1 分钟的振动运动 10 个周期，然后站立休息 30 秒。
NW 和 OW 之间的反应相似，因此将这些组合并进行分析（NW/OW：BMI<30kg/m）。总体而言，循环核心蛋白聚糖浓度更高（p<0.001）POST（8.80±0.19pg/mL），并且在 1H（8.66±0.19pg/mL）和 3H（8.68±0.19pg/mL）时显著更低（p's≤0.005），与 PRE（8.71±0.19pg/mL）相比。OB 组 POST 的核心蛋白聚糖（p=0.016）高于 NW/OW 组（8.82±0.18pg/mL）。总体而言，肌肉生长抑制素更高（p=0.002）POST（54.93±1.04pg/mL），24H 时更低（p<0.001）（54.93±1.04pg/mL）与 PRE（53.49±1.04pg/mL）相比。与男性和非西班牙裔黑人相比，女性和非西班牙裔白人的肌肉生长抑制素反应更低（p's≤0.001）。
单次全身振动可以促进核心蛋白聚糖和肌肉生长抑制素释放到循环中，这与传统运动的反应相似。此外，在评估全身振动对肌肉因子的反应时，应考虑肥胖、性别和种族。
