Bosch J, Bordas J M, Rigau J, Viola C, Mastai R, Kravetz D, Navasa M, Rodés J
Hepatology. 1986 Jul-Aug;6(4):667-72. doi: 10.1002/hep.1840060421.
Measurements of variceal pressure with a noninvasive endoscopic pressure gauge and by direct variceal puncture were performed in 20 cirrhotic patients with portal hypertension in the course of the first session of therapeutic sclerotherapy following an episode of variceal bleeding. Endoscopic gauge measurements of the pressure of esophageal varices gave similar values (15.5 +/- 2.7 mm Hg) than measurements by variceal puncture (15.4 +/- 2.4 mm Hg; not statistically significant), and there was a highly significant linear correlation between both measurements (r = 0.9, p less than 0.001). Azygos blood flow, that was markedly increased in these patients (852 +/- 399 ml per min), was directly related to variceal pressure (r = 0.73, p less than 0.01). Variceal pressure was significantly lower than portal pressure (18.8 +/- 5.0 mm Hg) (p less than 0.05), indicating that measurements of variceal pressure cannot substitute measurements of portal pressure. The study demonstrates that the noninvasive endoscopic gauge technique allows an accurate estimation of variceal pressure in patients with portal hypertension. This technique may provide additional useful information in the evaluation of portal hypertension as well as on the mechanism of variceal bleeding.
在20例门静脉高压症肝硬化患者发生静脉曲张出血后进行首次硬化治疗期间，使用无创内镜压力计和直接静脉曲张穿刺测量静脉曲张压力。内镜测量食管静脉曲张压力所得数值（15.5±2.7毫米汞柱）与静脉曲张穿刺测量值（15.4±2.4毫米汞柱）相似（无统计学显著性差异），且两种测量方法之间存在高度显著的线性相关性（r = 0.9，p＜0.001）。这些患者的奇静脉血流量显著增加（每分钟852±399毫升），与静脉曲张压力直接相关（r = 0.73，p＜0.01）。静脉曲张压力显著低于门静脉压力（18.8±5.0毫米汞柱）（p＜0.05），表明测量静脉曲张压力不能替代测量门静脉压力。该研究表明，无创内镜测量技术可准确估计门静脉高压症患者的静脉曲张压力。该技术在评估门静脉高压症以及静脉曲张出血机制方面可能提供额外有用信息。
