Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, 8 Gongti South Road, Chaoyang District, Beijing, 100020, China.
Department of Clinical Epidemiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
BMC Pulm Med. 2023 Jun 17;23(1):214. doi: 10.1186/s12890-023-02485-6.
The association between periodontitis and post-bronchodilator lung function is unclear. We aimed to determine the associations between symptoms of severe periodontitis (SSP) and post-bronchodilator lung function in the Chinese population.
A cross-sectional study (China Pulmonary Health study) was conducted from 2012 to 2015 in a large Chinese nationally representative sample of 49,202 participants aged 20-89 years. Data on demographic characteristics and periodontal symptoms of participants were collected by questionnaire. Participants who had at least one of the two severe symptoms (tooth mobility and natural tooth loss) in the past year were defined to have SSP, which was set as one variable for analyses. Post-bronchodilator lung function data including forced expiratory volume in 1 s (FEV) and forced vital capacity (FVC) were collected by spirometry.
The values of post-FEV, post-FVC and post-FEV/FVC of the participants with SSP were all significantly lower than the participants without SSP (all p < 0.001). SSP were significantly associated with post-FEV/FVC < 0.7 (p < 0.001). In the multiple regression analyses, SSP were still negatively associated with post-FEV(b = -0.04, 95%CI (-0.05 -0.03), p < 0.001), post-FEV/FVC (b = -0.45, 95%CI (-0.63, -0.28), p < 0.001) and significantly associated with post-FEV/FVC < 0.7 (OR = 1.08, 95%CI 1.01-1.16, p = 0.03) after full adjustment for potential confounders.
Our data suggest that SSP were negatively associated with post-bronchodilator lung function in the Chinese population. Longitudinal cohort studies are needed to confirm these associations in the future.
牙周炎与支气管扩张后肺功能之间的关系尚不清楚。本研究旨在确定中国人群中严重牙周炎（SSP）症状与支气管扩张后肺功能之间的关系。
本横断面研究（中国肺健康研究）于 2012 年至 2015 年在中国进行，纳入了一个大型的、具有全国代表性的 49202 名 20-89 岁参与者的样本。通过问卷收集参与者的人口统计学特征和牙周症状数据。在过去一年中至少有一个严重症状（牙齿松动和自然牙缺失）的参与者被定义为有 SSP，该症状作为一个变量进行分析。通过肺量计收集支气管扩张后肺功能数据，包括 1 秒用力呼气量（FEV）和用力肺活量（FVC）。
有 SSP 的参与者的 post-FEV、post-FVC 和 post-FEV/FVC 值均显著低于无 SSP 的参与者（均 p<0.001）。SSP 与 post-FEV/FVC<0.7 显著相关（p<0.001）。在多元回归分析中，SSP 仍与 post-FEV 呈负相关（b=-0.04，95%CI（-0.05，-0.03），p<0.001），与 post-FEV/FVC 呈负相关（b=-0.45，95%CI（-0.63，-0.28），p<0.001），与 post-FEV/FVC<0.7 显著相关（OR=1.08，95%CI 1.01，1.16，p=0.03）。在充分调整了潜在混杂因素后，仍存在上述关联。
本研究数据表明，SSP 与中国人群支气管扩张后肺功能呈负相关。未来需要进行纵向队列研究来进一步证实这些关联。
