Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha 410005, China.
Xiangya Hospital & Xiangya School of Medicine, Central South University, Changsha 410005, China.
Biomater Adv. 2023 Sep;152:213503. doi: 10.1016/j.bioadv.2023.213503. Epub 2023 Jun 7.
Zinc(Zn)-based materials have contributed greatly to the rapid advancements in tissue engineering. The qualities they possess that make them so beneficial include their excellent biodegradability, biocompatibility, anti-bacterial activity, among and several others. Biomedical materials that act as a foreign body, will inevitably cause host immune response when introduced to the human body. As the osteoimmunology develops, the immunomodulatory characteristics of biomaterials have become an appealing concept to improve implant-tissue interaction and tissue restoration. Recently, Zn-based materials have also displayed immunomodulatory functions, especially macrophage polarization states. It can promote the transformation of M1 macrophages into M2 macrophages to enhance the tissue regeneration and reconstruction. This review covers mainly Zn-based materials and their characteristics, including metallic Zn alloys and Zn ceramics. We highlight the current advancements in the type of immune responses, as well as the mechanisms, that are induced by Zn-based biomaterials, most importantly the regulation of innate immunity and the mechanism of promoting tissue regeneration. To this end, we discuss their applications in biomedicine, and conclude with an outlook on future research challenges.
锌（Zn）基材料在组织工程的快速发展中做出了巨大贡献。它们具有良好的生物降解性、生物相容性、抗菌活性等优点。作为异物的医用生物材料，引入人体后不可避免地会引起宿主免疫反应。随着骨免疫学的发展，生物材料的免疫调节特性已成为改善植入物-组织相互作用和组织修复的一个有吸引力的概念。最近，Zn 基材料也显示出免疫调节功能，特别是巨噬细胞极化状态。它可以促进 M1 巨噬细胞向 M2 巨噬细胞的转化，从而增强组织再生和重建。本综述主要涵盖 Zn 基材料及其特性，包括金属 Zn 合金和 Zn 陶瓷。我们强调了 Zn 基生物材料引起的免疫反应类型及其机制的最新进展，特别是固有免疫的调节和促进组织再生的机制。为此，我们讨论了它们在生物医学中的应用，并对未来的研究挑战进行了展望。
