Cognitive Ageing and Impairment Neuroscience Laboratory (CAIN), University of South Australia, Adelaide, South Australia, Australia.
Turner Institute for Brain & Mental Health, Monash University, Melbourne, Victoria, Australia.
Neurobiol Aging. 2023 Sep;129:157-167. doi: 10.1016/j.neurobiolaging.2023.05.011. Epub 2023 May 22.
High blood pressure variability (BPV) is a risk factor for cognitive decline and dementia, but its association with cortical thickness is not well understood. Here we use a topographical approach, to assess links between long-term BPV and cortical thickness in 478 (54% men at baseline) community dwelling older adults (70-88 years) from the ASPirin in Reducing Events in the Elderly NEURO sub-study. BPV was measured as average real variability, based on annual visits across three years. Higher diastolic BPV was significantly associated with reduced cortical thickness in multiple areas, including temporal (banks of the superior temporal sulcus), parietal (supramarginal gyrus, post-central gyrus), and posterior frontal areas (pre-central gyrus, caudal middle frontal gyrus), while controlling for mean BP. Higher diastolic BPV was associated with faster progression of cortical thinning across the three years. Diastolic BPV is an important predictor of cortical thickness, and trajectory of cortical thickness, independent of mean blood pressure. This finding suggests an important biological link in the relationship between BPV and cognitive decline in older age.
血压变异性（BPV）是认知能力下降和痴呆的一个危险因素，但它与皮质厚度之间的关系尚不清楚。在这里，我们使用地形学方法，评估了来自老年阿司匹林减少事件神经亚研究（ASPirin in Reducing Events in the Elderly NEURO sub-study）的 478 名（基线时 54%为男性）社区居住的老年成年人（70-88 岁）中，长期 BPV 与皮质厚度之间的联系。BPV 是根据三年中的年度就诊情况，以平均真实变异性来衡量的。较高的舒张压 BPV 与多个区域的皮质厚度降低显著相关，包括颞叶（上颞回的banks）、顶叶（缘上回、中央后回）和后额叶区域（中央前回、中额叶下部），同时控制平均血压。较高的舒张压 BPV 与三年内皮质变薄的进展速度加快有关。舒张压 BPV 是皮质厚度和皮质厚度变化轨迹的重要预测因子，独立于平均血压。这一发现表明，在老年人群中，BPV 和认知能力下降之间的关系存在重要的生物学联系。
