Sorbonne Université, CNRS, INSERM, Neurosciences Paris Seine - Institut de Biologie Paris Seine (NPS-IBPS), 9 quai Saint Bernard, 75005 Paris, France.
Sorbonne Université, CNRS, INSERM, Neurosciences Paris Seine - Institut de Biologie Paris Seine (NPS-IBPS), 9 quai Saint Bernard, 75005 Paris, France.
Neurobiol Dis. 2023 Aug;184:106207. doi: 10.1016/j.nbd.2023.106207. Epub 2023 Jun 17.
Over the last decades, lactate has emerged as important energy substrate for the brain fueling of neurons. A growing body of evidence now indicates that it is also a signaling molecule modulating neuronal excitability and activity as well as brain functions. In this review, we will briefly summarize how different cell types produce and release lactate. We will further describe different signaling mechanisms allowing lactate to fine-tune neuronal excitability and activity, and will finally discuss how these mechanisms could cooperate to modulate neuroenergetics and higher order brain functions both in physiological and pathological conditions.
在过去的几十年中，乳酸已成为为神经元提供燃料的大脑的重要能量底物。越来越多的证据表明，它也是一种信号分子，可以调节神经元的兴奋性和活性以及大脑功能。在这篇综述中，我们将简要总结不同细胞类型如何产生和释放乳酸。我们将进一步描述允许乳酸微调神经元兴奋性和活性的不同信号机制，并最终讨论这些机制如何在生理和病理条件下合作调节神经能量代谢和更高阶的大脑功能。
