PTPRO 通过去磷酸化 MET 抑制食管癌的淋巴结转移。
PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET.
机构信息
Institute of Precision Cancer Medicine and Pathology, And Department of Pathology, School of Medicine, And Minister of Education Key Laboratory of Tumor Molecular Biology, Jinan University, Guangzhou, Guangdong, China; Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Cancer Research Center, Shantou University Medical College, Shantou, Guangdong, China.
出版信息
Cancer Lett. 2023 Jul 28;567:216283. doi: 10.1016/j.canlet.2023.216283. Epub 2023 Jun 17.
Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPRO/p-MET had significantly poor prognosis, suggesting that PTPRO/p-MET can serve as an independent prognostic factor for patients with ESCC.
蛋白酪氨酸磷酸酯酶受体型 O（PTPRO）是一种膜结合的酪氨酸磷酸酯酶。值得注意的是，由于启动子超甲基化导致的表观遗传沉默的 PTPRO 常与恶性肿瘤有关。在这项研究中，我们使用细胞和动物模型以及患者样本证明 PTPRO 可以抑制食管鳞状细胞癌（ESCC）的转移。从机制上讲，PTPRO 通过去磷酸化 MET 激酶激活环中的 Y1234/1235 来抑制 MET 介导的转移。PTPRO/p-MET 患者的预后明显较差，表明 PTPRO/p-MET 可作为 ESCC 患者的独立预后因素。
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