黄曲霉毒素的生化活性（作者译）
[The biochemical activity of the aflatoxins (author's transl)].
作者信息
Reiss J
出版信息
Zentralbl Bakteriol B. 1978 Dec;167(5-6):435-42.
PMID:373323
Abstract
Results of experiments with the Salmonella typhimurium-liver microsome technique make it evident that the mutagenic and carcinogenic metabolite of aflatoxin B1 is aflatoxin B1-2,3-oxide. This compound forms adducts with guanine in DNA. There is a close relationship between the mutagenic activity and the hepatocarcinogenic property of the different aflatoxin derivatives.
摘要
鼠伤寒沙门氏菌-肝脏微粒体技术的实验结果表明，黄曲霉毒素B1的诱变和致癌代谢产物是黄曲霉毒素B1-2,3-环氧化物。该化合物与DNA中的鸟嘌呤形成加合物。不同黄曲霉毒素衍生物的诱变活性和肝癌致癌特性之间存在密切关系。
相似文献
1
[The biochemical activity of the aflatoxins (author's transl)].黄曲霉毒素的生化活性（作者译）
Zentralbl Bakteriol B. 1978 Dec;167(5-6):435-42.
2
The reduced mutagenicity of aflatoxin B1 due to hydroxylation: observations on five Salmonella typhimurium tester strains.黄曲霉毒素B1因羟基化导致的致突变性降低：对五株鼠伤寒沙门氏菌测试菌株的观察
Cancer Lett. 1979 Aug;7(4):221-5. doi: 10.1016/s0304-3835(79)80084-1.
3
Comparative mutagenicity of palmotoxin Bo and aflatoxins B1 and M1.棕榈毒素Bo与黄曲霉毒素B1和M1的比较致突变性。
J Environ Pathol Toxicol. 1979 Mar-Apr;2(4):1099-107.
4
5
The mutagenicity of aflatoxin Q1 to Salmonella typhimurium TA 100 with or without rat or human liver microsomal preparations.黄曲霉毒素Q1在有或无大鼠或人肝微粒体制剂存在的情况下对鼠伤寒沙门氏菌TA 100的致突变性。
Res Commun Chem Pathol Pharmacol. 1986 Oct;54(1):101-13.
6
Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential.黄曲霉毒素的致突变性与其代谢及致癌潜力相关。
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2241-4. doi: 10.1073/pnas.73.7.2241.
7
The direct mutagenicity of aflatoxin B1 and metabolites to Salmonella typhimurium: structure mutagenicity relationships and mechanisms of action.黄曲霉毒素B1及其代谢产物对鼠伤寒沙门氏菌的直接致突变性：结构-致突变性关系及作用机制
Res Commun Chem Pathol Pharmacol. 1987 Jul;57(1):55-76.
8
Reduction of mutagenic activity of aflatoxins after UV-irradiation.紫外线照射后黄曲霉毒素诱变活性的降低。
Acta Biol Med Ger. 1979;38(9):1239-42.
9
10
Strain differences in the metabolic activation of aflatoxin B1 in the rat.大鼠中黄曲霉毒素B1代谢活化的品系差异。
Xenobiotica. 1987 Feb;17(2):199-208. doi: 10.3109/00498258709043929.
Zotero 插件