Imajo Ikumi, Yamada Tomohiro, Chikui Toru, Kiyoshima Tamotsu, Ito Mamoru, Kohashi Kenichi, Sakamoto Eiji, Oda Yoshinao
Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Oral and Maxillofacial Radiology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Oncol Lett. 2023 Jun 7;26(1):318. doi: 10.3892/ol.2023.13904. eCollection 2023 Jul.
Synovial sarcoma (SS) is a malignant soft tissue tumor that usually arises in the para-articular regions of the extremities. Only nine cases of SS in the mandible have been reported to date. The present study described a case of SS arising from the left mandible. A 54-year-old woman was referred to Kyushu University Hospital (Fukuoka, Japan) with a complaint of numbness in the left mental nerve area. Computed tomography revealed replacement of the left mandibular bone marrow with soft tissue and destruction of the mandibular canal. Magnetic resonance imaging revealed an isointense mass on T1-weighted images and hyperintensity on T2-weighted images. The tumor showed homogeneous enhancement. A biopsy was performed, and monophasic SS was diagnosed based on immunohistochemical staining features and genetic analysis. Hemimandible dissection and supraomophyoid neck resection were performed with fibular osteocutaneous flap reconstruction, followed by adjuvant chemotherapy. There was no evidence of recurrence or distant metastases. The present study also reviewed the clinical, imaging, histological, and immunohistochemical features of the SS in the mandible.
滑膜肉瘤（SS）是一种恶性软组织肿瘤，通常发生于四肢关节旁区域。迄今为止，仅报道过9例下颌骨滑膜肉瘤病例。本研究描述了1例源自左下颌骨的滑膜肉瘤病例。一名54岁女性因左侧颏神经区域麻木而被转诊至九州大学医院（日本福冈）。计算机断层扫描显示左侧下颌骨髓被软组织取代，下颌管破坏。磁共振成像显示在T1加权图像上为等信号肿块，在T2加权图像上为高信号。肿瘤呈均匀强化。进行了活检，并根据免疫组织化学染色特征和基因分析诊断为单相滑膜肉瘤。实施了半侧下颌骨切除术和肩胛舌骨上颈清扫术，并采用腓骨骨皮瓣重建，随后进行辅助化疗。没有复发或远处转移的证据。本研究还回顾了下颌骨滑膜肉瘤的临床、影像学、组织学和免疫组织化学特征。
