Agarwal Radhika, Joshi Shrirang S
Physiology, All India Institute of Medical Sciences Rishikesh, Rishikesh, IND.
Emergency Medicine, All India Institute of Medical Sciences, New Delhi, IND.
Cureus. 2023 May 18;15(5):e39168. doi: 10.7759/cureus.39168. eCollection 2023 May.
Bisphenol analogues are widely used in consumer products such as disposable dinnerware, canned food, personal care products, bottled beverages, and more, and dietary exposure is the main pathway. Bisphenol A is used to manufacture synthetic resins and commercial plastics in large quantities. According to epidemiological and animal studies, bisphenols disrupt the reproductive, immunological, and metabolic systems. These analogues are estrogenic like Bisphenol A, although human studies are limited. We did a thorough search of the literature on the toxicity of bisphenol on reproductive and endocrine systems in pregnancy, focusing particularly on human studies. Hence, we present a comprehensive literature review on this topic. During our literature search, three epidemiological studies and one human observational study demonstrated a substantial link between bisphenol toxicity and recurrent miscarriages. The aforementioned research shows that bisphenol may harm pregnancy and cause miscarriages. We believe this is the first literature review on the topic.
双酚类似物广泛应用于一次性餐具、罐头食品、个人护理产品、瓶装饮料等消费品中，饮食接触是主要途径。双酚A大量用于制造合成树脂和商业塑料。根据流行病学和动物研究，双酚会干扰生殖、免疫和代谢系统。这些类似物与双酚A一样具有雌激素活性，尽管人体研究有限。我们全面检索了关于双酚对孕期生殖和内分泌系统毒性的文献，尤其关注人体研究。因此，我们针对该主题进行了全面的文献综述。在文献检索过程中，三项流行病学研究和一项人体观察性研究表明双酚毒性与复发性流产之间存在显著关联。上述研究表明双酚可能危害妊娠并导致流产。我们认为这是关于该主题的第一篇文献综述。
