a Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health , State University of New York at Albany , Empire State Plaza , Albany , NY 12201-0509 , USA.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(2):319-29. doi: 10.1080/19440049.2013.868611. Epub 2014 Jan 30.
Bisphenol A (BPA) is a high-production-volume chemical that is widely used in polycarbonate plastics and epoxy food-can coatings. Following several studies that have reported adverse effects of BPA over the past decade, other bisphenol analogues, such as bisphenol F (BPF), bisphenol S (BPS), bisphenol AF (BPAF), and bisphenol B (BPB), have been gradually developed as substitutes for BPA in several applications. Nevertheless, few studies have reported on the occurrence of compounds other than BPA in foodstuffs. In this study, 289 food samples (13 categories: cereals and cereal products, meat and meat products, fish and seafood, eggs, milk and milk products, bean products, fruits, vegetables, cookies/snacks, beverages, cooking oils, condiments, and others), collected from nine cities in China, were analysed for eight bisphenol analogues using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). BPA and BPF were found widely in foodstuffs at concentrations ranging from below the limit of quantitation (LOQ) to 299 ng g(-1) (mean = 4.94 ng g(-1)) and from below the LOQ to 623 ng g(-1) (mean = 2.50 ng g(-1)), fresh weight, respectively. The highest total concentrations of bisphenols (∑BPs: sum of eight bisphenols) were found in the category of vegetables that included canned products (mean = 27.0 ng g(-1)), followed by fish and seafood (16.5 ng g(-1)) and beverages (15.6 ng g(-1)). ∑BP concentrations (mean = 2-3 ng g(-1)) in milk and milk products, cooking oils, and eggs were low. Food samples sold in metallic cans contained higher mean ∑BP concentrations (56.9 ng g(-1)) in comparison with those packaged in glass (0.43 ng g(-1)), paper (11.9 ng g(-1)), or plastic (6.40 ng g(-1)). The daily dietary intakes of bisphenols were estimated, based on the mean concentrations measured and daily consumption rates of foods, to be 646 and 664 ng kg(-1) bw day(-1) for men and women, respectively.
双酚 A（BPA）是一种高产量的化学物质，广泛用于聚碳酸酯塑料和环氧树脂食品罐涂料。在过去十年的几项研究报告 BPA 的不良影响后，其他双酚类似物，如双酚 F（BPF）、双酚 S（BPS）、双酚 AF（BPAF）和双酚 B（BPB），已逐渐被开发为 BPA 在某些应用中的替代品。然而，很少有研究报告食品中除 BPA 以外的化合物的存在。在这项研究中，从中国九个城市采集了 289 个食品样本（13 个类别：谷物和谷物制品、肉类和肉类制品、鱼类和海鲜、蛋类、牛奶和奶制品、豆类制品、水果、蔬菜、饼干/小吃、饮料、食用油、调味料和其他），使用高效液相色谱-串联质谱法（HPLC-MS/MS）对 8 种双酚类似物进行了分析。在食品中广泛发现了 BPA 和 BPF，浓度范围从低于定量限（LOQ）到 299ng g(-1)（平均值=4.94ng g(-1)）和从低于 LOQ 到 623ng g(-1)（平均值=2.50ng g(-1)），新鲜重量。在包括罐头产品在内的蔬菜类别中发现了最高的双酚总浓度（∑BPs：八种双酚的总和）（平均值=27.0ng g(-1)），其次是鱼类和海鲜（16.5ng g(-1)）和饮料（15.6ng g(-1)）。牛奶和奶制品、食用油和蛋类中∑BP 浓度（平均值=2-3ng g(-1)）较低。与包装在玻璃（0.43ng g(-1)）、纸（11.9ng g(-1)）或塑料（6.40ng g(-1)）中的食品相比，金属罐中销售的食品样品含有更高的平均∑BP 浓度（56.9ng g(-1)）。基于测量的平均浓度和食品的日消耗量，估计双酚的日膳食摄入量为男性和女性分别为 646 和 664ng kg(-1) bw day(-1)。
