Barré P E, Prichard S
Int J Artif Organs. 1986 May;9(3):167-72.
A 61-year-old male hemodialysis patient developed the syndrome of aluminum intoxication including bone pain, fractures, proximal myopathy, progressive anemia and expressive aphasia. Serum aluminum was 130 micrograms/l and rose to 445 micrograms/l after the administration of 2 grams of desferrioxamine. Bone biopsy of the iliac crest revealed severe osteomalacia, heavy staining for aluminum and a bone aluminum content of 229 mg/kg dry bone. Treatment with combined hemofiltration and desferrioxamine administration led to a marked clinical improvement and a repeat bone biopsy striking healing of the osteomalacia with a bone aluminum content of 11 mg/kg dry bone.
一名61岁的男性血液透析患者出现了铝中毒综合征，包括骨痛、骨折、近端肌病、进行性贫血和表达性失语。血清铝含量为130微克/升，在给予2克去铁胺后升至445微克/升。髂嵴骨活检显示严重骨软化、铝染色浓和骨铝含量为229毫克/千克干骨。联合血液滤过和给予去铁胺治疗导致临床显著改善，再次进行骨活检显示骨软化显著愈合，骨铝含量为11毫克/千克干骨。
