Veiga Filipa, Leite Paula Maria, Ferrão José, Prates Marcelo M, Fonseca Luís S
Oral Surgery, Centro Hospitalar Universitário de Lisboa Central, Lisbon, PRT.
Cureus. 2023 May 18;15(5):e39186. doi: 10.7759/cureus.39186. eCollection 2023 May.
Crohn's disease is an inflammatory granulomatous and chronic disease characterized by inflammation of the gastrointestinal mucosa with extra-intestinal manifestations. Oral lesions seem to occur as specific lesions like lip swelling, cobblestone or tag lesions, or nonspecific lesions like ulcers. The present case report describes an orofacial Crohn's disease case, a rare presentation of Crohn's disease, managed with infliximab. Oral Crohn's disease refers to the spread of manifestations of Crohn's disease and could precede other signs. Physicians have to be aware of oral mucosal changes. The treatment options are based on the use of corticosteroids, immune-modulators and biologics. The best plan and therapy to control oral Crohn's disease requires early and precise diagnosis.
克罗恩病是一种炎症性肉芽肿性慢性病,其特征为胃肠道黏膜炎症并伴有肠外表现。口腔病变似乎表现为特异性病变,如唇部肿胀、鹅卵石样或赘生物样病变,或非特异性病变,如溃疡。本病例报告描述了一例口面部克罗恩病病例,这是克罗恩病的一种罕见表现,采用英夫利昔单抗进行治疗。口腔克罗恩病是指克罗恩病表现的扩散,可能先于其他体征出现。医生必须意识到口腔黏膜的变化。治疗选择基于使用皮质类固醇、免疫调节剂和生物制剂。控制口腔克罗恩病的最佳方案和治疗需要早期准确的诊断。