Hoyland Alec, Barnett Nelson V, Roop Benjamin W, Alexandrou Danae, Caplan Myah, Mills Jacob, Parrell Benjamin, Chari Divya A, Lammert Adam C
Department of Biomedical Engineering (BME)Worcester Polytechnic Institute (WPI) Worcester MA 01609 USA.
Clarifai, Inc. Wilmington DE 19808 USA.
IEEE Open J Eng Med Biol. 2023 May 18;4:116-118. doi: 10.1109/OJEMB.2023.3275051. eCollection 2023.
This study validates an approach to characterizing the sounds experienced by tinnitus patients via reverse correlation, with potential for characterizing a wider range of sounds than currently possible. Ten normal-hearing subjects assessed the subjective similarity of random auditory stimuli and target tinnitus-like sounds ("buzzing" and "roaring"). Reconstructions of the targets were obtained by regressing subject responses on the stimuli, and were compared for accuracy to the frequency spectra of the targets using Pearson's [Formula: see text]. Reconstruction accuracy was significantly higher than chance across subjects: buzzing: [Formula: see text] (mean [Formula: see text] s.d.), [Formula: see text], [Formula: see text]; roaring: [Formula: see text], [Formula: see text], [Formula: see text]; combined: [Formula: see text], [Formula: see text], [Formula: see text]. Reverse correlation can accurately reconstruct non-tonal tinnitus-like sounds in normal-hearing subjects, indicating its potential for characterizing the sounds experienced by patients with non-tonal tinnitus.
本研究验证了一种通过反向关联来表征耳鸣患者所经历声音的方法，该方法有可能表征比目前所能做到的更广泛的声音范围。十名听力正常的受试者评估了随机听觉刺激与类似耳鸣的目标声音（“嗡嗡声”和“轰鸣声”）的主观相似性。通过将受试者对刺激的反应进行回归分析来获得目标声音的重构，并使用皮尔逊[公式：见正文]将其与目标声音的频谱进行准确性比较。跨受试者的重构准确率显著高于随机水平：嗡嗡声：[公式：见正文]（均值[公式：见正文]标准差），[公式：见正文]，[公式：见正文]；轰鸣声：[公式：见正文]，[公式：见正文]，[公式：见正文]；综合：[公式：见正文]，[公式：见正文]，[公式：见正文]。反向关联能够准确重构听力正常受试者中类似非纯音耳鸣的声音，这表明其在表征非纯音耳鸣患者所经历声音方面具有潜力。
