Stein A, Engell A, Junghoefer M, Wunderlich R, Lau P, Wollbrink A, Rudack C, Pantev C
Institute for Biomagnetism and Biosignalanalysis, University of Muenster, Germany.
Department of Otolaryngology, University Hospital, Muenster, Germany.
Clin Neurophysiol. 2015 May;126(5):1007-15. doi: 10.1016/j.clinph.2014.08.017. Epub 2014 Sep 6.
Notch-filtered music has been shown to induce frequency-specific inhibition. Here, we investigated which cortical structures are affected by tailor-made notched music (TMNM) in tinnitus patients and how this inhibition-induced plasticity develops over time.
Nine subjects suffering from chronic tonal tinnitus listened to music passing through a notch-filter centered at the patient's individual tinnitus frequency (TMNM) for three hours on three consecutive days. Before and after each listening session, a tone at the tinnitus frequency and a control tone of 500 Hz were presented in the magnetoencephalograph. Subjective tinnitus loudness was measured via visual analog scales.
TMNM exposure reduced subjective tinnitus loudness and neural activity evoked by the tinnitus tone in temporal, parietal and frontal regions within the N1m time interval. Reduction of temporal and frontal activation correlated significantly with tinnitus loudness decline. Reduction of tinnitus related neural activity persisted and accumulated over three days.
Inhibition-induced plasticity occurs in a cortical network, known to be crucial for tinnitus perception. This cortical reorganization evolves fast and accumulates across sessions.
This study extends previous work on inhibition-induced plasticity, as it demonstrates the involvement of parietal and frontal areas and discovers a cumulative effect of cortical reorganization in tinnitus patients.
已证实带通滤波音乐可诱导频率特异性抑制。在此，我们研究了耳鸣患者中哪些皮质结构会受到特制带通音乐（TMNM）的影响，以及这种抑制诱导的可塑性如何随时间发展。
9名患有慢性音调性耳鸣的受试者连续三天每天听三小时通过以患者个体耳鸣频率为中心的带通滤波器的音乐（TMNM）。在每次听音乐前后，在脑磁图中呈现耳鸣频率的音调以及500赫兹的对照音调。通过视觉模拟量表测量主观耳鸣响度。
TMNM暴露降低了主观耳鸣响度以及在N1m时间间隔内颞叶、顶叶和额叶区域中耳鸣音调诱发的神经活动。颞叶和额叶激活的降低与耳鸣响度下降显著相关。与耳鸣相关的神经活动的降低在三天内持续并累积。
抑制诱导的可塑性发生在一个已知对耳鸣感知至关重要的皮质网络中。这种皮质重组发展迅速且在各次疗程中累积。
本研究扩展了先前关于抑制诱导可塑性的研究，因为它证明了顶叶和额叶区域的参与，并发现了耳鸣患者皮质重组的累积效应。
