Ortiz-Cam Lizzie, Jones-Engel Lisa, Mendoza Patricia, Castillo-Neyra Ricardo
National Forest and Wildlife Service (SERFOR), Lima, Peru.
School of Veterinary Medicine and Zoothecnic, Cayetano Heredia Peruvian University, Lima, Peru.
One Health. 2023 May 31;17:100571. doi: 10.1016/j.onehlt.2023.100571. eCollection 2023 Dec.
Measles infections can cause significant morbidity and mortality in human and monkey populations. The endemicity of measles in human populations and viral circulation within populations of free-living monkeys may have important repercussions for potential zoonotic transmission events and for the long-term health of monkey populations. Yet, there has not yet been a rigorous investigation of the dynamics of measles transmission where human and monkey populations coexist. In this study, to determine the difference in seroprevalence of the measles virus across different contexts of human-monkey contact, we analyzed serum samples collected from 56 apparently healthy monkeys who occupied diverse contexts, with different degrees of human-monkey contact, in Bangladesh. This is the first report of measles virus seroprevalence in monkeys in Bangladesh. We found a clear association between measles virus seropositivity in monkeys and the context in which they interact with humans. Seroprevalence was the lowest in wild areas (0.0%) and increased in shrines (4.8%), urban areas (5.9%), and was highest among monkeys who are used as performance animals (50.0%). This work suggests that a One Health approach informed by local interspecies transmission dynamics is necessary to develop strategies that both improve measles vaccination coverage, achieve long-term surveillance in monkey populations, and prevent measles spillback to monkeys. This approach aims to inform conservation efforts and protect the long-term health of human and monkey populations.
麻疹感染可在人类和猴群中导致严重发病和死亡。人类群体中麻疹的地方性流行以及自由生活猴群中的病毒传播可能对潜在的人畜共患病传播事件以及猴群的长期健康产生重要影响。然而，尚未对人类和猴群共存地区的麻疹传播动态进行严格调查。在本研究中，为了确定在不同人类与猴接触情况下麻疹病毒血清阳性率的差异，我们分析了从孟加拉国56只表面健康的猴子采集的血清样本，这些猴子所处环境多样，与人类的接触程度不同。这是孟加拉国关于猴子中麻疹病毒血清阳性率的首次报告。我们发现猴子中麻疹病毒血清阳性与它们与人类互动的环境之间存在明显关联。血清阳性率在野生区域最低（0.0%），在神庙中有所上升（4.8%），在城市地区为（5.9%），在用作表演动物的猴子中最高（50.0%）。这项工作表明，基于当地物种间传播动态的“同一健康”方法对于制定既能提高麻疹疫苗接种覆盖率、对猴群进行长期监测又能防止麻疹病毒回传给猴子的策略是必要的。这种方法旨在为保护工作提供信息并保护人类和猴群的长期健康。
