Department of Biotechnology, School of Biotechnology and Genetic Engineering, Bharathiar University, Coimbatore 641046, Tamil Nadu, India.
Food Chem Toxicol. 2011 Apr;49(4):991-8. doi: 10.1016/j.fct.2011.01.005. Epub 2011 Jan 8.
Lindane is an organochlorine pesticide that persists in the environment, bioaccumulate through food chain and has a risk of causing adverse effects to human health and the environment. It induces cell damage by producing free radicals and reactive oxygen species. The aim of the present study is to investigate the protective effect of gallic acid (a plant derived polyphenol) against lindane induced hepatic and renal toxicity in rats. Liver damage was assessed by hepatic serum marker enzymes like SGOT, SGPT and ALP and histopathological observation. Renal damage was observed by histopathological examination and serum markers like creatinine and urea. Treatment with lindane increased the levels of lipid peroxidation, serum marker enzyme activity with a concomitant decrease in GSH, CAT, SOD, GPx and GST. Histological alterations were also observed in kidney and liver tissue with lindane treatment. Co-treatment of gallic acid significantly prevented the lindane induced alterations in kidney and liver tissues with a decrease in LPO, serum marker enzyme activity and a significant increase in antioxidant levels. These results suggest that gallic acid has protective effect over lindane induced oxidative damage in rat liver and kidney.
林丹是一种有机氯农药，它在环境中持久存在，通过食物链生物累积，并有可能对人类健康和环境造成不良影响。它通过产生自由基和活性氧来诱导细胞损伤。本研究旨在探讨没食子酸（一种植物来源的多酚）对大鼠林丹诱导的肝肾功能毒性的保护作用。通过检测血清标志物酶（如 SGOT、SGPT 和 ALP）和组织病理学观察来评估肝损伤。通过组织病理学检查和血清标志物（如肌酐和尿素）来观察肾损伤。林丹处理增加了脂质过氧化水平、血清标志物酶活性，同时降低了 GSH、CAT、SOD、GPx 和 GST。林丹处理还导致肾脏和肝脏组织的组织学改变。用没食子酸共同处理显著防止了林丹引起的肾脏和肝脏组织的改变，降低了 LPO、血清标志物酶活性，并显著增加了抗氧化剂水平。这些结果表明，没食子酸对大鼠肝和肾的林丹诱导的氧化损伤具有保护作用。
