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伴有肺栓塞的双克隆性华氏巨球蛋白血症罕见病例报告

Rare presentation of double-clonal Waldenström macroglobulinemia with pulmonary embolism: A case report.

作者信息

Sun Yan, Meng Fan-Jun, Huang Jun-Xia, Yan Xue-Shen, Zhao Xia, Zhou Jing-Jing, Gao Yan

机构信息

Department of Hematology, The Affiliated Hospital of Qingdao University, No. 1677 of Wutaishan Road, Huangdao District, Qingdao 266000, Shandong, China.

出版信息

Open Life Sci. 2023 Jun 14;18(1):20220619. doi: 10.1515/biol-2022-0619. eCollection 2023.

DOI:10.1515/biol-2022-0619
PMID:37333483
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10276544/
Abstract

Waldenström macroglobulinemia (WM) rarely leads to pulmonary embolism. Due to its low incidence, the underlying pathophysiology, prognosis, and optimal treatment remain largely unexplored and uninvestigated. In this study, a patient with a double-clonal WM, a rare subtype, presented with pulmonary embolism. The patient had a small number of plasma cells without morphological abnormalities, and an effective therapeutic response was observed. Nonetheless, the clinical prognosis requires a long-term follow-up.

摘要

华氏巨球蛋白血症（WM）很少导致肺栓塞。由于其发病率低，其潜在的病理生理学、预后及最佳治疗方法在很大程度上仍未得到探索和研究。在本研究中，一名患有罕见双克隆WM亚型的患者出现了肺栓塞。该患者有少量形态无异常的浆细胞，并观察到有效的治疗反应。尽管如此，临床预后仍需要长期随访。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/10276544/9338f740905e/j_biol-2022-0619-fig005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/10276544/a9df725e0d11/j_biol-2022-0619-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/10276544/34acd19fb176/j_biol-2022-0619-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/10276544/4e97d8ba7cda/j_biol-2022-0619-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/10276544/b3b41548ecf6/j_biol-2022-0619-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/10276544/9338f740905e/j_biol-2022-0619-fig005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/10276544/a9df725e0d11/j_biol-2022-0619-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/10276544/34acd19fb176/j_biol-2022-0619-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/10276544/4e97d8ba7cda/j_biol-2022-0619-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/10276544/b3b41548ecf6/j_biol-2022-0619-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/10276544/9338f740905e/j_biol-2022-0619-fig005.jpg

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A multidisciplinary case report of multiple myeloma with renal and cardiac involvement: a look beyond amyloidosis.多学科病例报告：多发性骨髓瘤伴肾和心脏受累——超越淀粉样变性的观察。
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