Böttger Sarah Jane, Förstner Bernd R, Szalek Laura, Koller-Schlaud Kristin, Rapp Michael A, Tschorn Mira
Social and Preventive Medicine, Department of Sports and Health Sciences, University of Potsdam, Potsdam, Germany.
DZPG (German Center of Mental Health), partner site Berlin/Potsdam, Potsdam, Germany.
Front Hum Neurosci. 2023 Jun 2;17:1184978. doi: 10.3389/fnhum.2023.1184978. eCollection 2023.
While a growing body of research is adopting Research Domain Criteria (RDoC)-related methods and constructs, there is still a lack of comprehensive reviews on the state of published research on Positive Valence Systems (PVS) and Negative Valence Systems (NVS) in mood and anxiety disorders consistent with the RDoC framework.
Five electronic databases were searched to identify peer-reviewed publications covering research on "positive valence" and "negative valence" as well as "valence," "affect," and "emotion" for individuals with symptoms of mood and anxiety disorders. Data was extracted with a focus on disorder, domain, (sub-) constructs, units of analysis, key results, and study design. Findings are presented along four sections, distinguishing between primary articles and reviews each for PVS, NVS, and cross-domain PVS and NVS.
A total of 231 abstracts were identified, and 43 met the inclusion criteria for this scoping review. Seventeen publications addressed research on PVS, seventeen on NVS, and nine covered cross-domain research on PVS and NVS. Psychological constructs were typically examined across different units of analysis, with the majority of publications incorporating two or more measures. Molecular, genetic, and physiological aspects were mainly investigated via review articles, primary articles focused on self-report, behavioral, and, to a lesser extent, physiological measures.
This present scoping review shows that mood and anxiety disorders were actively studied using a range of genetic, molecular, neuronal, physiological, behavioral, and self-report measures within the RDoC PVS and NVS. Results highlight the essential role of specific cortical frontal brain structures and of subcortical limbic structures in impaired emotional processing in mood and anxiety disorders. Findings also indicate overall limited research on NVS in bipolar disorders and PVS in anxiety disorders, a majority of self-report studies, and predominantly observational studies. Future research is needed to develop more RDoC-consistent advancements and intervention studies targeting neuroscience-driven PVS and NVS constructs.
尽管越来越多的研究采用了与研究领域标准（RDoC）相关的方法和结构，但仍缺乏对符合RDoC框架的情绪和焦虑障碍中积极效价系统（PVS）和消极效价系统（NVS）已发表研究状况的全面综述。
检索了五个电子数据库，以识别同行评审的出版物，这些出版物涵盖了对有情绪和焦虑障碍症状个体的“积极效价”和“消极效价”以及“效价”“情感”和“情绪”的研究。提取数据时重点关注障碍、领域、（子）结构、分析单位、关键结果和研究设计。研究结果分为四个部分呈现，区分了关于PVS、NVS以及跨领域PVS和NVS的原始文章和综述。
共识别出231篇摘要，43篇符合本范围综述的纳入标准。17篇出版物涉及PVS研究，17篇涉及NVS研究，9篇涵盖PVS和NVS的跨领域研究。心理结构通常在不同的分析单位中进行研究，大多数出版物纳入了两种或更多种测量方法。分子、遗传和生理方面主要通过综述文章进行研究，原始文章主要关注自我报告、行为测量，在较小程度上关注生理测量。
本范围综述表明，在RDoC的PVS和NVS中，情绪和焦虑障碍通过一系列遗传、分子、神经元、生理、行为和自我报告测量方法得到了积极研究。结果突出了特定的额叶皮质脑结构和皮质下边缘结构在情绪和焦虑障碍中受损情绪处理中的重要作用。研究结果还表明，双相情感障碍中对NVS的研究总体有限，焦虑障碍中对PVS的研究也有限，大多数是自我报告研究，且主要是观察性研究。未来需要开展更多符合RDoC的进展性研究以及针对神经科学驱动的PVS和NVS结构的干预研究。
