Gu Jin Yu, Han Fei, Chen Si-Yu, Zhang Qing
Department of Orthopaedic, The Hospital of Wang Jing, China Academy of Chinese Medical Sciences, Beijing, People's Republic of China.
Department of Orthopaedic, The Hospital of Guang An Men, China Academy of Chinese Medical Sciences, Beijing, People's Republic of China.
J Pain Res. 2023 Jun 12;16:1961-1977. doi: 10.2147/JPR.S392840. eCollection 2023.
Clinical treatment of knee osteoarthritis has gained great interest, and numerous clinical studies have been reported. Few studies have described the detailed characterizations of clinical trials on knee osteoarthritis. This study is to identify, visualize, and characterize the clinical trials in knee osteoarthritis research.
Articles published in recent two decades were extracted from the Web of Science core collection database using a query based on MeSH terms and topics of knee osteoarthritis and clinical trial. Basic characteristics of publications were analyzed based on the publication year, authors, institutions, counties, and keywords covered in the article. CiteSpace and VOS viewer were used for data visualization. The data were retrieved on May 28, 2022.
A total of 1972 trials on knee osteoarthritis were identified. The number of publications has experienced rapid growth in the past two decades. America, England, and China had strong contributions in publication. , and were highly cited and bellwether journals. Clustering mapping of the collaborative network, co-citation, and co-occurrence analyses showed that the research hotspots are mainly focused on disease-modifying medications, intra-articular injections, physical therapy for symptom control, lifestyle intervention, Chinese medicine treatment, and knee replacement.
Clinical treatments of knee OA are evolving. Pharmacologic therapy, intra-articular therapy, nonpharmacologic therapy including exercise or diet, self-management programs, Chinese medicine treatment, and knee replacement were highly represented in clinical trials of knee OA. Adjustment of combination therapy may be the next study focus in the future.
膝关节骨关节炎的临床治疗备受关注，已有大量临床研究报道。但很少有研究描述膝关节骨关节炎临床试验的详细特征。本研究旨在识别、可视化并描述膝关节骨关节炎研究中的临床试验。
使用基于膝关节骨关节炎和临床试验的医学主题词（MeSH）及主题的查询，从Web of Science核心合集数据库中提取近二十年发表的文章。根据文章的发表年份、作者、机构、国家和关键词分析出版物的基本特征。使用CiteSpace和VOS viewer进行数据可视化。数据于2022年5月28日检索。
共识别出1972项膝关节骨关节炎试验。过去二十年出版物数量迅速增长。美国、英国和中国在出版物方面贡献显著。[此处原文缺失具体期刊名称]、[此处原文缺失具体期刊名称]和[此处原文缺失具体期刊名称]是高被引和引领性期刊。合作网络、共被引和共现分析的聚类图显示，研究热点主要集中在改善病情的药物、关节内注射、症状控制的物理治疗、生活方式干预、中医治疗和膝关节置换。
膝关节骨关节炎的临床治疗在不断发展。药物治疗、关节内治疗、包括运动或饮食在内的非药物治疗、自我管理项目、中医治疗和膝关节置换在膝关节骨关节炎临床试验中占比很高。联合治疗的调整可能是未来的下一个研究重点。
