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Hyperbaric oxygen induced experimental epilepsy: the age factor.

作者信息

Masserini C, Rosina E, Morosini F, Altamura A C, Cazzullo C L, Torcello L

出版信息

Ital J Neurol Sci. 1986 Jun;7(3):343-8. doi: 10.1007/BF02340873.

Abstract

Two methods of inducing convulsions were used in male Swiss albino mice of different ages: exposure to hyperbaric oxygen and pentylenetetrazole treatment. Hyperbaric oxygen proved to be a valid model of experimental epilepsy with an age-dependent trend. The youngest mice presented a much longer convulsion latency time than the adult mice but the curve of distribution of latency time versus age showed progressively increasing sensitivity. Pentylenetetrazole induced convulsions, apart from the youngest subgroup, without variations by age. Hyperbaric oxygen convulsions provide an interesting model for the study not only of the neurochemistry of convulsions but also of the membrane changes that occur in the course of cerebral maturation and aging.

摘要

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Status epilepticus and brain maturation.癫痫持续状态与脑成熟
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Experiments on the convulsant and anaesthetic effects of oxygen.关于氧气惊厥和麻醉作用的实验。
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Hyperbaric oxygen toxicity in newborn and developing mice.新生及发育中小鼠的高压氧毒性
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