Ricci G F, De Feo M R, Mecarelli O
Rev Electroencephalogr Neurophysiol Clin. 1984 Dec;14(3):187-95. doi: 10.1016/s0370-4475(84)80003-9.
The development of a limbic and a generalized tonic-clonic form of epilepsy, induced by systemic injections of kainic acid and pentylenetetrazol respectively, has been studied in developing rats. The purpose of this research was to investigate the correlations between the maturational stages of the CNS and the electro-clinical manifestations of epilepsy and status epilepticus. In both models of epilepsy, the electro-clinical patterns of seizures typical of the adult animal were reached as early as the third week of life. During the first weeks, atypical behavioural and EEG epileptic manifestations were observed. An attempt has been made to compare the experimental results with the electro-clinical epileptic signs of the infant, in order to suggest some neurophysiological explanations of the peculiar aspects of infantile epilepsy.
分别通过全身注射海藻酸和戊四氮在发育中的大鼠身上诱导出边缘性癫痫和全身性强直阵挛性癫痫，并对其进行了研究。本研究的目的是探讨中枢神经系统成熟阶段与癫痫及癫痫持续状态的电临床表型之间的相关性。在这两种癫痫模型中，早在出生后第三周就出现了成年动物典型的癫痫发作电临床模式。在最初几周，观察到了非典型的行为和脑电图癫痫表现。为了对婴儿癫痫的特殊方面提出一些神经生理学解释，已尝试将实验结果与婴儿的电临床癫痫体征进行比较。
