作为一种有前途的抗肥胖治疗方法在 knockout 小鼠中。

as a promising anti-obesity treatment in knockout mice.

机构信息

Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang, Republic of Korea.

Department of Food Science and Nutrition, College of Human Ecology, Pusan National University, Busan, Republic of Korea.

出版信息

Front Endocrinol (Lausanne). 2023 May 26;14:1167285. doi: 10.3389/fendo.2023.1167285. eCollection 2023.

DOI:10.3389/fendo.2023.1167285

PMID:37334306

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10273273/

Abstract

INTRODUCTION

The therapeutic effects and mechanisms of () extracts have been examined concerning inflammation, photoaging, and gastritis; however, their effect on obesity is still being investigated.

METHODS

We administered a methanol extract of (MED) orally to knockout (KO) mice for 4 weeks to investigate the therapeutic effects on obesity, weight gain, fat accumulation, lipid metabolism, inflammatory response, and β-oxidation.

RESULTS

In KO mice, MED significantly reduced weight gains, food intake, and total cholesterol and glyceride levels. Similar reductions in fat weights and adipocyte sizes were also observed. Furthermore, MED treatment reduced liver weight, lipid droplet numbers, the expressions of adipogenesis and lipogenesis-related genes, and the expressions of lipolysis regulators in liver tissues. Moreover, the iNOS-mediated COX-2 induction pathway, the inflammasome pathway, and inflammatory cytokine levels were reduced, but β-oxidation was increased, in the livers of MED-treated KO mice.

CONCLUSION

The results of this study suggest that MED ameliorates obesity and has considerable potential as an anti-obesity treatment.

摘要

简介

（）提取物的治疗效果和机制已在炎症、光老化和胃炎方面得到了检验；然而，其对肥胖的影响仍在研究中。

方法

我们用甲醇对（MED）进行提取并对基因敲除（KO）小鼠进行口服给药，持续四周，以研究其对肥胖、体重增加、脂肪积累、脂代谢、炎症反应和 β-氧化的治疗效果。

结果

在 KO 小鼠中，MED 显著降低了体重增加、食物摄入以及总胆固醇和甘油三酯水平。脂肪重量和脂肪细胞大小也出现了类似的减少。此外，MED 处理还降低了肝脏重量、脂滴数量、脂肪生成和脂肪生成相关基因的表达以及肝组织中脂肪分解调节剂的表达。此外，在 MED 处理的 KO 小鼠的肝脏中，iNOS 介导的 COX-2 诱导途径、炎症小体途径和炎症细胞因子水平降低，而 β-氧化增加。