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具有高抗氧化活性的[具体物质]对人新生儿成纤维细胞（NHDF）和裸鼠紫外线诱导光老化的治疗作用

Therapeutic Effects of with High Antioxidative Activity Against UV-Induced Photoaging of NHDF Cells and Nude Mice.

作者信息

Lee Su Jin, Kim Ji Eun, Choi Yun Ju, Gong Jeong Eun, Park So Hae, Douangdeuane Bounleuane, Souliya Onevilay, Park Ju Min, Lee Hee Seob, Kim Bae-Hwan, Hwang Dae Youn

机构信息

Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science/Longevity & Wellbeing Research Center, Pusan National University, Miryang 50463, Korea.

Life and Industry Convergence Research Institute/Laboratory Animal Center, Pusan National University, Miryang 50463, Korea.

出版信息

Antioxidants (Basel). 2021 May 17;10(5):791. doi: 10.3390/antiox10050791.

DOI:10.3390/antiox10050791
PMID:34067673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8157063/
Abstract

To investigate the therapeutic effects of methanol extracts of Roxb. (MED) against UV-induced photoaging, we assessed for alterations in the antioxidant activity, anti-apoptotic effects, ECM modulation, skin appearances, and anti-inflammatory response in normal human dermal fibroblast (NHDF) cells and nude mice orally treated with MED. High levels of tannin content and high free radical scavenging activity to DPPH were determined in MED, while seven active components, namely, gallic acid, bergenin, ellagic acid, ε-viniferin, asiatic acid, oleanolic acid, and 2α-hydroxyursolic acid, were identified using LC-MS analyses. UV-induced alterations in the NO concentration, SOD activity, and Nrf2 expression were remarkably recovered in MED-treated NHDF cells. Moreover, the decreased number of apoptotic cells and G2/M phase arrest were observed in the UV + MED-treated groups. Similar recoveries were detected for β-galactosidase, MMP-2/9 expression, and intracellular elastase activity. Furthermore, MED treatment induced suppression of the COX-2-induced iNOS mediated pathway, expression of inflammatory cytokines, and inflammasome activation in UV-radiated NHDF cells. The anti-photoaging effects observed in NHDF cells were subsequently evaluated and validated in UV + MED-treated nude mice through skin phenotypes and histopathological structure analyses. Taken together, these results indicate that MED exerts therapeutic effects against UV-induced photoaging and has the potential for future development as a treatment for photoaging.

摘要

为了研究长梗紫麻甲醇提取物（MED）对紫外线诱导的光老化的治疗效果，我们评估了口服MED的正常人皮肤成纤维细胞（NHDF）和裸鼠的抗氧化活性、抗凋亡作用、细胞外基质调节、皮肤外观和抗炎反应的变化。MED中检测到高水平的单宁含量和对DPPH的高自由基清除活性，同时使用液相色谱-质谱分析鉴定了七种活性成分，即没食子酸、岩白菜素、鞣花酸、ε-葡萄素、积雪草苷、齐墩果酸和2α-羟基熊果酸。在MED处理的NHDF细胞中，紫外线诱导的NO浓度、SOD活性和Nrf2表达的变化得到显著恢复。此外，在紫外线+MED处理组中观察到凋亡细胞数量减少和G2/M期阻滞。β-半乳糖苷酶、MMP-2/9表达和细胞内弹性蛋白酶活性也有类似的恢复。此外，MED处理可抑制紫外线照射的NHDF细胞中COX-2诱导的iNOS介导的途径、炎性细胞因子的表达和炎性小体的激活。随后，通过皮肤表型和组织病理学结构分析，在紫外线+MED处理的裸鼠中评估并验证了在NHDF细胞中观察到的抗光老化作用。综上所述，这些结果表明MED对紫外线诱导的光老化具有治疗作用，并且有潜力在未来发展成为光老化的治疗方法。

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