Zhu Jing, Huang Fei, Hu Yonglin, Qiao Wei, Guan Yingchao, Zhang Zhi-Jun, Liu Su, Liu Ying
Department of Rehabilitation Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, JiangSu Province, 226001, People's Republic of China.
Department of Rehabilitation Medicine, Nantong Health College of Jiangsu Province, Nantong, JiangSu Province, 226010, People's Republic of China.
J Inflamm Res. 2023 Jun 13;16:2477-2489. doi: 10.2147/JIR.S413264. eCollection 2023.
Secondary chronic neuropathic pain (NP) in addition to sensory, motor, or autonomic dysfunction can significantly reduce quality of life after spinal cord injury (SCI). The mechanisms of SCI-related NP have been studied in clinical trials and with the use of experimental models. However, in developing new treatment strategies for SCI patients, NP poses new challenges. The inflammatory response following SCI promotes the development of NP. Previous studies suggest that reducing neuroinflammation following SCI can improve NP-related behaviors. Intensive studies of the roles of non-coding RNAs in SCI have discovered that ncRNAs bind target mRNA, act between activated glia, neuronal cells, or other immunocytes, regulate gene expression, inhibit inflammation, and influence the prognosis of NP.
除感觉、运动或自主神经功能障碍外，继发性慢性神经性疼痛（NP）会显著降低脊髓损伤（SCI）后的生活质量。SCI相关NP的机制已在临床试验和实验模型中进行了研究。然而，在为SCI患者开发新的治疗策略时，NP带来了新的挑战。SCI后的炎症反应促进了NP的发展。先前的研究表明，减轻SCI后的神经炎症可以改善与NP相关的行为。对非编码RNA在SCI中的作用的深入研究发现，ncRNAs与靶mRNA结合，在活化的神经胶质细胞、神经元细胞或其他免疫细胞之间起作用，调节基因表达，抑制炎症，并影响NP的预后。
