长链非编码 RNA 介导的不同脂肪细胞中的脂肪生成。
LncRNA-Mediated Adipogenesis in Different Adipocytes.
机构信息
College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.
出版信息
Int J Mol Sci. 2022 Jul 5;23(13):7488. doi: 10.3390/ijms23137488.
Long-chain noncoding RNAs (lncRNAs) are RNAs that do not code for proteins, widely present in eukaryotes. They regulate gene expression at multiple levels through different mechanisms at epigenetic, transcription, translation, and the maturation of mRNA transcripts or regulation of the chromatin structure, and compete with microRNAs for binding to endogenous RNA. Adipose tissue is a large and endocrine-rich functional tissue in mammals. Excessive accumulation of white adipose tissue in mammals can cause metabolic diseases. However, unlike white fat, brown and beige fats release energy as heat. In recent years, many lncRNAs associated with adipogenesis have been reported. The molecular mechanisms of how lncRNAs regulate adipogenesis are continually investigated. In this review, we discuss the classification of lncRNAs according to their transcriptional location. lncRNAs that participate in the adipogenesis of white or brown fats are also discussed. The function of lncRNAs as decoy molecules and RNA double-stranded complexes, among other functions, is also discussed.
长链非编码 RNA（lncRNA）是指不编码蛋白质的 RNA，广泛存在于真核生物中。它们通过不同的机制在表观遗传、转录、翻译以及 mRNA 转录本的成熟或染色质结构的调节等多个水平上调节基因表达，并与 microRNA 竞争结合内源性 RNA。脂肪组织是哺乳动物中一个大型的富含内分泌的功能组织。哺乳动物中白色脂肪组织的过度积累会导致代谢性疾病。然而，与白色脂肪不同的是，棕色和米色脂肪会释放能量以产生热量。近年来，已经报道了许多与脂肪生成相关的 lncRNA。lncRNA 调节脂肪生成的分子机制仍在不断研究中。在这篇综述中，我们根据其转录位置讨论了 lncRNA 的分类。还讨论了参与白色或棕色脂肪脂肪生成的 lncRNA。还讨论了 lncRNA 作为诱饵分子和 RNA 双链复合物等功能。
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