Laboratory of Cardiovascular Physiology and Pharmacology, Federal University of Bahia, Salvador.
Gonçalo Moniz Institute, Oswaldo Cruz Foundation - FIOCRUZ, Bahia, Brazil.
J Hypertens. 2023 Sep 1;41(9):1351-1370. doi: 10.1097/HJH.0000000000003487. Epub 2023 Jun 9.
Transient receptor potential (TRP) channels are nonselective cation channels and participate in various physiological roles. Thus, changes in TRP channel function or expression have been linked to several disorders. Among the many TRP channel subtypes, the TRP ankyrin type 1 (TRPA1), TRP melastatin type 8 (TRPM8), and TRP vanilloid type 1 (TRPV1) channels are temperature-sensitive and recognized as thermo-TRPs, which are expressed in the primary afferent nerve. Thermal stimuli are converted into neuronal activity. Several studies have described the expression of TRPA1, TRPM8, and TRPV1 in the cardiovascular system, where these channels can modulate physiological and pathological conditions, including hypertension. This review provides a complete understanding of the functional role of the opposing thermo-receptors TRPA1/TRPM8/TRPV1 in hypertension and a more comprehensive appreciation of TRPA1/TRPM8/TRPV1-dependent mechanisms involved in hypertension. These channels varied activation and inactivation have revealed a signaling pathway that may lead to innovative future treatment options for hypertension and correlated vascular diseases.
瞬时受体电位 (TRP) 通道是非选择性阳离子通道，参与多种生理作用。因此，TRP 通道功能或表达的变化与多种疾病有关。在众多 TRP 通道亚型中，TRP 锚蛋白型 1 (TRPA1)、TRP 巨蛋白型 8 (TRPM8) 和 TRP 香草素型 1 (TRPV1) 通道对温度敏感，被认为是热敏型 TRP，它们在初级传入神经中表达。热刺激被转化为神经元活动。几项研究描述了 TRPA1、TRPM8 和 TRPV1 在心血管系统中的表达，这些通道可以调节包括高血压在内的生理和病理状况。本综述全面阐述了 opposing thermo-receptors TRPA1/TRPM8/TRPV1 在高血压中的功能作用，以及更全面地了解了 TRPV1 依赖的机制在高血压中的作用。这些通道的不同激活和失活揭示了一条信号通路，可能为高血压和相关血管疾病带来创新的未来治疗选择。
