Liu Xiaozhen, Feng Changyun, Yan Li, Cao Jili, Zhu Xinping, Li Mingqian, Zhao Guizhi
Department of Medical and Radiation Oncology, Linyi People's Hospital, Linyi, 276000, China.
Department of Pediatrics, Linyi Maternal and Child Health Hospital, Linyi, 276000, China.
Clin Exp Med. 2025 Mar 25;25(1):94. doi: 10.1007/s10238-025-01632-z.
Ca, as critical second messengers in biological processes, plays a pivotal role in the regulation of diverse cellular signaling pathways. The dysregulation of calcium signaling is intricately linked to the progression of various cancers. The capacity of Ca to modulate cell death and proliferation, along with its potential for pharmacological manipulation, presents a promising avenue for the development of novel cancer therapeutics. This review provides a comprehensive overview of the classification of Ca channels and their mechanisms of action in oncogenesis, explores the application of Ca blockers in cancer treatment, and underscores the importance of conducting further clinical trials.
钙作为生物过程中的关键第二信使，在多种细胞信号通路的调节中起着关键作用。钙信号失调与各种癌症的进展密切相关。钙调节细胞死亡和增殖的能力及其药理学操纵潜力，为新型癌症治疗药物的开发提供了一条有前景的途径。本综述全面概述了钙通道的分类及其在肿瘤发生中的作用机制，探讨了钙阻滞剂在癌症治疗中的应用，并强调了开展进一步临床试验的重要性。
