循环自身抗体在阿尔茨海默病中对淀粉样β的诊断潜力。

The Diagnostic Potential of Circulating Autoantibodies to Amyloid-β in Alzheimer's Disease.

机构信息

Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.

Shigatse Branch, Xinqiao Hospital, Third Military Medical University, Shigatse, China.

出版信息

J Alzheimers Dis. 2023;94(2):537-546. doi: 10.3233/JAD-230252.

DOI:10.3233/JAD-230252

PMID:37334604

Abstract

BACKGROUND

The profile of naturally occurring antibodies to amyloid-β (NAbs-Aβ) is altered in patients with Alzheimer's disease (AD). However, the diagnostic potential of NAbs-Aβ for AD is not clear yet.

OBJECTIVE

This study aims to investigate the diagnostic capacities of NAbs-Aβ for AD.

METHODS

A total of 40 AD patients and 40 cognitively normal (CN) controls were enrolled in this study. Levels of NAbs-Aβ were detected by ELISA. The correlations of NAbs-Aβ levels with cognitive function and AD-associated biomarkers were examined by Spearman correlation analysis. Diagnostic abilities of NAbs-Aβ were evaluated by the receiver operating characteristic (ROC) curve analyses. The integrative diagnostic models were established by logistic regression models.

RESULTS

We found that NAbs-Aβ7-18 had the highest diagnostic capability (AUC = 0.72) among all single NAbs-Aβ. The combined model (NAbs-Aβ7-18, NAbs-Aβ19-30, and NAbs-Aβ25-36) had a noticeable improvement (AUC = 0.84) in the diagnostic capacity compared with each single NAbs-Aβ.

CONCLUSION

NAbs-Aβs are promising in the diagnosis of AD. Further investigations are needed to confirm the translational potential of this diagnostic strategy.

摘要

背景

在阿尔茨海默病（AD）患者中，淀粉样蛋白-β（Aβ）的天然抗体（NAbs-Aβ）谱发生改变。然而，NAbs-Aβ 用于 AD 的诊断潜力尚不清楚。

目的

本研究旨在探讨 NAbs-Aβ 对 AD 的诊断能力。

方法

本研究纳入了 40 名 AD 患者和 40 名认知正常（CN）对照者。采用 ELISA 法检测 NAbs-Aβ 水平。通过 Spearman 相关分析，研究 NAbs-Aβ 水平与认知功能和 AD 相关生物标志物的相关性。通过受试者工作特征（ROC）曲线分析评估 NAbs-Aβ 的诊断能力。通过逻辑回归模型建立综合诊断模型。