Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
Shigatse Branch, Xinqiao Hospital, Third Military Medical University, Shigatse, China.
J Alzheimers Dis. 2023;94(2):537-546. doi: 10.3233/JAD-230252.
The profile of naturally occurring antibodies to amyloid-β (NAbs-Aβ) is altered in patients with Alzheimer's disease (AD). However, the diagnostic potential of NAbs-Aβ for AD is not clear yet.
This study aims to investigate the diagnostic capacities of NAbs-Aβ for AD.
A total of 40 AD patients and 40 cognitively normal (CN) controls were enrolled in this study. Levels of NAbs-Aβ were detected by ELISA. The correlations of NAbs-Aβ levels with cognitive function and AD-associated biomarkers were examined by Spearman correlation analysis. Diagnostic abilities of NAbs-Aβ were evaluated by the receiver operating characteristic (ROC) curve analyses. The integrative diagnostic models were established by logistic regression models.
We found that NAbs-Aβ7-18 had the highest diagnostic capability (AUC = 0.72) among all single NAbs-Aβ. The combined model (NAbs-Aβ7-18, NAbs-Aβ19-30, and NAbs-Aβ25-36) had a noticeable improvement (AUC = 0.84) in the diagnostic capacity compared with each single NAbs-Aβ.
NAbs-Aβs are promising in the diagnosis of AD. Further investigations are needed to confirm the translational potential of this diagnostic strategy.
在阿尔茨海默病（AD）患者中，淀粉样蛋白-β（Aβ）的天然抗体（NAbs-Aβ）谱发生改变。然而，NAbs-Aβ 用于 AD 的诊断潜力尚不清楚。
本研究旨在探讨 NAbs-Aβ 对 AD 的诊断能力。
本研究纳入了 40 名 AD 患者和 40 名认知正常（CN）对照者。采用 ELISA 法检测 NAbs-Aβ 水平。通过 Spearman 相关分析，研究 NAbs-Aβ 水平与认知功能和 AD 相关生物标志物的相关性。通过受试者工作特征（ROC）曲线分析评估 NAbs-Aβ 的诊断能力。通过逻辑回归模型建立综合诊断模型。
我们发现，在所有单 NAbs-Aβ 中，NAbs-Aβ7-18 具有最高的诊断能力（AUC=0.72）。与每个单 NAbs-Aβ 相比，联合模型（NAbs-Aβ7-18、NAbs-Aβ19-30 和 NAbs-Aβ25-36）在诊断能力上有明显提高（AUC=0.84）。
NAbs-Aβ 对 AD 的诊断有一定价值。需要进一步的研究来证实这种诊断策略的转化潜力。
