Department of Neurology, Philipps-University Marburg, Marburg, Germany.
Transl Psychiatry. 2013 Mar 5;3(3):e236. doi: 10.1038/tp.2012.151.
There is evidence that naturally occurring antibodies directed against Aβ (nAbs-Aβ) have a role in Aβ-metabolism and Aβ-clearance. The presence of nAbs-Aβ leads to a reduction in amyloid fibrillation and thus a reduction in their toxicity. We investigated the effects of nAbs-Aβ in respect to oligomerization and used the Tg2576 transgenic mouse model in order to investigate the rapid effect with a single-dose (24 h) on oligomer breakdown and cytokine secretion along with immunohistochemical characterization of synaptic plasticity. nAbs-Aβ were able to reduce toxic oligomer concentration with an increase in Aβ-monomers. Cytokine secretion was significantly reduced. Synaptic plasticity was also improved after administration of nAbs. Finally, single treatment lead to a significant improvement in cognition. This study demonstrates the efficacy of nAbs-Aβ and presents evidence that several hallmarks of the disease are targeted by nAbs-Aβ.
有证据表明，针对 Aβ 的天然存在的抗体（nAbs-Aβ）在 Aβ 代谢和 Aβ 清除中起作用。nAbs-Aβ 的存在导致淀粉样纤维的减少，从而降低其毒性。我们研究了 nAbs-Aβ 在寡聚化方面的作用，并使用 Tg2576 转基因小鼠模型来研究单次剂量（24 小时）对寡聚体分解的快速作用以及细胞因子分泌情况，同时对突触可塑性进行免疫组织化学特征分析。nAbs-Aβ 能够增加 Aβ 单体的浓度，从而减少有毒的寡聚体浓度。细胞因子分泌显著减少。给予 nAbs 后，突触可塑性也得到改善。最后，单次治疗可显著改善认知能力。这项研究证明了 nAbs-Aβ 的疗效，并提供了证据表明 nAbs-Aβ 针对疾病的几个特征。
