School of Pharmacy, Zunyi Medical University, Zunyi 563000, China.
Institute of Marine Biomedicine/Postdoctoral Innovation Practice Base, Shenzhen Polytechnic, Shenzhen 518055, China.
Org Biomol Chem. 2023 Jul 5;21(26):5413-5418. doi: 10.1039/d3ob00511a.
An inverse-electron-demand aza-Diels-Alder reaction between 4,4-dicyano-2-methylenebut-3-enoates and 1,3,5-triazinanes under catalyst-free and additive-free conditions was developed, which provided a highly convenient and straightforward method to construct a series of polyfunctionalized tetrahydropyridines in high yields. This strategy features numerous advantages, including high efficiency, good functional group tolerance, broad substrate scope, and environmentally friendly conditions.
在无催化剂和添加剂的条件下，开发了 4,4-二氰基-2-亚甲基丁-3-烯酸酯和 1,3,5-三嗪烷之间的逆电子需求氮杂-Diels-Alder 反应，为构建一系列多功能化的四氢吡啶提供了一种高效、直接的方法，产率很高。该策略具有许多优点，包括高效率、良好的官能团耐受性、广泛的底物范围和环境友好的条件。
