Cai Huixin, Du Jian, Su Miaomiao, Meng Juan, An Weina, Shi Haoxi, Fan Weiguang
Clinical Laboratory, Baoding No. 1 Central Hospital, Baoding, China.
Infection Division, The People's Hospital of Baoding, Baoding, China.
AIDS Res Hum Retroviruses. 2023 Oct;39(10):575-580. doi: 10.1089/AID.2023.0035. Epub 2023 Jul 7.
Along with the co-circulation of dominant HIV-1 strains (CRF01_AE and CRF07_BC) in China, an increasing number of second-generation recombinants are being detected, especially among men who have sex with men (MSM). In this study, we identified a unique CRF01_AE/CRF07_BC recombinant from a HIV-1-positive man (BDD015A) infected through homosexual transmission in Baoding city, Hebei Province. Analysis of the near full-length genome sequence of the recombinant revealed five segments divided by four breakpoints, with two regions of CRF07_BC inserted into the pol and env regions of the CRF01_AE backbone. Three CRF01_AE segments (I, III, and V) clustered within the cluster 4 lineage, which mainly circulated among MSM in China. This recombinant differed from previously reported CRF01_ AE and CRF07_BC recombinant forms. The continuous emergence of novel recombinants increases the genetic complexity of HIV-1 in Hebei. Further measures are needed to monitor the molecular epidemiological characteristics of HIV-1 to help control the spread of infections.
随着中国主要HIV-1毒株（CRF01_AE和CRF07_BC）的共同流行，越来越多的第二代重组毒株被检测到，尤其是在男男性行为者（MSM）中。在本研究中，我们从河北省保定市一名通过同性传播感染的HIV-1阳性男性（BDD015A）中鉴定出一种独特的CRF01_AE/CRF07_BC重组毒株。对该重组毒株近乎全长的基因组序列分析显示，其由四个断点分隔为五个片段，其中CRF07_BC的两个区域插入到CRF01_AE主干的pol和env区域。三个CRF01_AE片段（I、III和V）聚集在4型分支内，该分支主要在中国的男男性行为者中流行。这种重组毒株与先前报道的CRF01_AE和CRF07_BC重组形式不同。新型重组毒株的不断出现增加了河北HIV-1的遗传复杂性。需要采取进一步措施监测HIV-1的分子流行病学特征，以帮助控制感染传播。
