Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, College of Life Sciences, Yan'an University, Yan'an, China.
Yan'an University Affiliated Hospital, Yan'an, China.
AIDS Res Hum Retroviruses. 2021 Dec;37(12):973-977. doi: 10.1089/AID.2021.0058. Epub 2021 Apr 30.
Owing to co-epidemic of CRF01_AE and CRF07_BC in China, increasing numbers of the second-generation recombinants between them have been identified especially among sexual population. In this study, we identified a unique CRF01_AE/CRF07_BC recombinants from a male HIV-1 positive individual (18YA004) infected by heterosexual contact in Yan'an city, Shaanxi province. The near full-length genome analyses showed 18YA004 was divided into six fragments by five breakpoints located in the , , , and gene, respectively. Three CRF01_AE segments (segments I, III, and V) were all clustered within the cluster 4a lineage, exclusively circulating among MSM in the northern China. Coupled with our previous finding of CRF01_AE/C recombinant in Yan'an city, the emergence of CRF01_AE/CRF07_BC strain further suggested coexistence of multiple HIV-1 genotypes here. Therefore, it is necessary to continue monitoring the molecular epidemiology of HIV-1 among high-risk groups to obtain a better understanding of the genetic complexity and transmission of HIV-1 in this region.
由于中国 CRF01_AE 和 CRF07_BC 的共同流行，越来越多的它们之间的第二代重组体被发现，特别是在性人群中。在这项研究中，我们从一名通过异性接触感染 HIV-1 的男性阳性个体（18YA004）中鉴定出一种独特的 CRF01_AE/CRF07_BC 重组体。该个体来自陕西省延安市。全长近基因组分析显示，18YA004 通过位于 、 、 和 基因的五个断点被分为六个片段。三个 CRF01_AE 片段（片段 I、III 和 V）均聚类在 4a 谱系内，仅在北方的男男性行为者中传播。结合我们之前在延安市发现的 CRF01_AE/C 重组体，CRF01_AE/CRF07_BC 株的出现进一步表明，该地区存在多种 HIV-1 基因型。因此，有必要继续监测高危人群中 HIV-1 的分子流行病学，以更好地了解该地区 HIV-1 的遗传复杂性和传播。
