Lim Joshua, Bupphathong Sasinan, Huang Wei, Lin Chih-Hsin
Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.
Department of Orthodontics, Rutgers School of Dental Medicine, Newark, New Jersey, USA.
Tissue Eng Part B Rev. 2023 Dec;29(6):710-722. doi: 10.1089/ten.TEB.2023.0072. Epub 2023 Jul 6.
Three-dimensional (3D) bioprinting, or additive manufacturing, is a rapid fabrication technique with the foremost objective of creating biomimetic tissue and organ replacements in hopes of restoring normal tissue function and structure. Generating the engineered organs with an infrastructure that is similar to that of the real organs can be beneficial to simulate the functional organs that work inside our bodies. Photopolymerization-based 3D bioprinting, or photocuring, has emerged as a promising method in engineering biomimetic tissues due to its simplicity, and noninvasive and spatially controllable approach. In this review, we investigated types of 3D printers, mainstream materials, photoinitiators, phototoxicity, and selected tissue engineering applications of 3D photopolymerization bioprinting.
三维（3D）生物打印，即增材制造，是一种快速制造技术，其首要目标是制造仿生组织和器官替代品，以期恢复正常的组织功能和结构。构建具有与真实器官相似结构的工程器官，有助于模拟在我们体内发挥作用的功能性器官。基于光聚合的3D生物打印，即光固化，因其操作简单、无创且具有空间可控性，已成为工程化仿生组织的一种有前景的方法。在本综述中，我们研究了3D打印机的类型、主流材料、光引发剂、光毒性以及3D光聚合生物打印在组织工程中的选定应用。
