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立体光刻3D生物打印

Stereolithography 3D Bioprinting.

作者信息

Kumar Hitendra, Kim Keekyoung

机构信息

School of Engineering, University of British Columbia, Kelowna, BC, Canada.

Department of Mechanical and Manufacturing Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada.

出版信息

Methods Mol Biol. 2020;2140:93-108. doi: 10.1007/978-1-0716-0520-2_6.

Abstract

Stereolithography (SLA) 3D bioprinting has emerged as a prominent bioprinting method addressing the requirements of complex tissue fabrication. This chapter addresses the advancement in SLA 3D bioprinting in concurrent with the development of novel photocrosslinkable biomaterials with enhanced physical and chemical properties. We discuss the cytocompatible photoinitiators operating in the wide spectrum of the ultraviolet (UV) and the visible light and high-resolution dynamic mask projection systems with a suitable illumination source. The potential of SLA 3D bioprinting has been explored in various themes, like bone and neural tissue engineering and in the development of controlled microenvironments to study cell behavior. The flexible design and versatility of SLA bioprinting makes it an attractive bioprinting process with myriad possibilities and clinical applications.

摘要

立体光刻(SLA)3D生物打印已成为一种突出的生物打印方法,可满足复杂组织制造的要求。本章介绍了SLA 3D生物打印技术的进展,以及具有增强物理和化学性质的新型光交联生物材料的开发。我们讨论了在紫外(UV)和可见光宽光谱范围内运行的细胞相容性光引发剂,以及具有合适照明源的高分辨率动态掩膜投影系统。SLA 3D生物打印的潜力已在各种主题中得到探索,如骨和神经组织工程以及用于研究细胞行为的可控微环境的开发。SLA生物打印的灵活设计和多功能性使其成为一种具有无数可能性和临床应用的有吸引力的生物打印工艺。

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