Mulero Patricia, Maroto-Izquierdo Sergio, Redondo Natán, Gonzalo-Benito Hugo, Chavarría-Miranda Alba, Calvo Hugo, Cabero María I, Hernandez Marita, Nieto María Luisa, Tellez Nieves
Department of Neurology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Departament of Health Sciences, Universidad Europea Miguel de Cervantes, Valladolid, Spain.
Neurol Sci. 2023 Nov;44(11):3997-4000. doi: 10.1007/s10072-023-06896-5. Epub 2023 Jun 19.
Multiple sclerosis (MS) is a dysimmune and neurodegenerative disease of the central nervous system that continues to be one of the main causes of non-traumatic disability in young people despite the recent availability of highly effective drugs. Exercise-based interventions seem to have a positive impact on the course of the disease although pathophysiological mechanisms responsible for this benefit remain unclear. This is a longitudinal study to examine the effects of a short-term training program on neurofilament plasma levels, a biomarker of axonal destruction, measured using the ultrasensitive single molecule array (SiMoA). Eleven patients completed a 6-week supervised resistance-training program of 18 sessions that consisted of 3 sets of 8-10 repetitions of 7 exercises. Median plasma neurofilament levels significantly decreased from baseline (6.61 pg/ml) to 1 week after training intervention (4.44 pg/ml), and this effect was maintained after 4 weeks of detraining (4.38 pg/ml). These results suggest a neuroprotective effect of resistance training in this population and encourage us to investigate further the beneficial impact of physical exercise and to emphasize the importance of lifestyle in MS.
多发性硬化症（MS）是一种中枢神经系统的免疫失调和神经退行性疾病，尽管最近有了高效药物，但它仍然是年轻人非创伤性残疾的主要原因之一。基于运动的干预措施似乎对疾病进程有积极影响，尽管这种益处的病理生理机制尚不清楚。这是一项纵向研究，旨在使用超灵敏单分子阵列（SiMoA）检测短期训练计划对神经丝血浆水平（轴突破坏的生物标志物）的影响。11名患者完成了一个为期6周、共18节的有监督的抗阻训练计划，该计划包括7项运动，每组8 - 10次重复，共3组。血浆神经丝水平中位数从基线（6.61 pg/ml）显著下降至训练干预后1周（4.44 pg/ml），并且在停止训练4周后（4.38 pg/ml）这种效果得以维持。这些结果表明抗阻训练对该人群具有神经保护作用，并鼓励我们进一步研究体育锻炼的有益影响，并强调生活方式在多发性硬化症中的重要性。
