Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, room 3202 D.Belo Horizonte, Pampulha, MG, Brazil.
Cell Cultivation Laboratory, Universidade Federal do Pará, Belém, Pará, Brazil.
Lasers Med Sci. 2023 Jun 19;38(1):141. doi: 10.1007/s10103-023-03806-1.
High-power diode laser emerges as a promising approach to the treatment of oral leukoplakia (OL); however, its short- and long-term effects have been barely explored. This study evaluated the postoperative endpoints and the recurrence rate of high-power diode laser treatment in a well-defined series of patients with OL.
A prospective analysis was performed on 22 individuals comprising 31 OL. The lesions were irradiated using the following protocol: Indium-Gallium-Arsenide diode laser, 808 nm, continuous-wave mode, 1.5-2.0 W, 780.0 ± 225.1 J, and 477.1 ± 131.8 s. Postoperative pain was assessed with a visual analog scale at three endpoints. Clinical follow-up was performed on all patients and the Kaplan-Meier test was used to analyze the probability of recurrence.
The series consisted mostly of women (72.7%) with a mean age of 62.8 years. A single laser session was performed in 77.4% of cases. The median score on the scale that assessed pain on the 1st, 14th and 42nd postoperative day was 4, 1, and 0, respectively. The mean follow-up period per lesion was 28.6 months (range: 2-53 months). A complete response was observed in 93.5% of OL cases, while 6.5% had recurrence. The probability of recurrence at 39 months was 6.7%. No patient experienced malignant transformation.
High-power diode laser for the treatment of OL is safe and effective during the trans- and postoperative period. These findings represent an alternative approach to the management of OL, mainly because a low recurrence rate was observed.
高功率二极管激光治疗口腔白斑病（OL）有很大的潜力；然而，其短期和长期效果尚未得到充分探索。本研究评估了高功率二极管激光治疗在一组明确的 OL 患者中的术后终点和复发率。
对 22 名 31 例 OL 患者进行前瞻性分析。采用以下方案对病变进行照射：铟镓砷二极管激光，808nm，连续波模式，1.5-2.0W，780.0±225.1J，477.1±131.8s。在三个时间点使用视觉模拟量表评估术后疼痛。对所有患者进行临床随访，并使用 Kaplan-Meier 检验分析复发概率。
该系列主要由女性（72.7%）组成，平均年龄为 62.8 岁。77.4%的病例进行了单次激光治疗。评估术后第 1、14 和 42 天疼痛的量表中位数分别为 4、1 和 0。每个病变的平均随访时间为 28.6 个月（范围：2-53 个月）。93.5%的 OL 病例观察到完全缓解，6.5%的病例复发。39 个月时的复发概率为 6.7%。无患者发生恶性转化。
高功率二极管激光治疗 OL 在治疗期间和治疗后是安全有效的。这些发现为 OL 的治疗提供了一种替代方法，主要是因为观察到复发率较低。
