肿瘤浸润淋巴细胞中 Liprin-α1 的表达与 HPV 阳性口咽鳞状细胞癌患者的生存改善相关。
Liprin-α1 Expression in Tumor-Infiltrating Lymphocytes Associates with Improved Survival in Patients with HPV-Positive Oropharyngeal Squamous Cell Carcinoma.
机构信息
Department of Pathology, University of Helsinki and Helsinki University Hospital, PO Box 21, 00014, Helsinki, Finland.
Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
出版信息
Head Neck Pathol. 2023 Sep;17(3):647-657. doi: 10.1007/s12105-023-01565-7. Epub 2023 Jun 19.
BACKGROUND
Liprin-α1 is a scaffold protein involved in cell adhesion, motility, and invasion in malignancies. Liprin-α1 inhibits the expression of metastatic suppressor CD82 in cancers such as oral carcinoma, and the expression of these proteins has been known to correlate negatively. The role of these proteins has not been previously studied in human papillomavirus (HPV)-related head and neck cancers. Our aim was to assess the clinical and prognostic role of liprin-α1 and CD82 in HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) in comparison to HPV-negative OPSCC.
METHODS
The data included 139 OPSCC patients treated at the Helsinki University Hospital (HUS) during 2012-2016. Immunohistochemistry was utilized in HPV determination and in biomarker assays. Overall survival (OS) was used in the survival analysis.
RESULTS
Stronger expression of liprin-α1 in tumor-infiltrating lymphocytes (TILs) was linked to lower cancer stage (p < 0.001) and HPV positivity (p < 0.001). Additionally, we found an association between elevated expression of liprin-α1 and weak expression of CD82 in tumor cells (p = 0.029). In survival analysis, we found significant correlation between favorable OS and stronger expression of liprin-α1 in TILs among the whole patient cohort (p < 0.001) and among HPV-positive patients (p = 0.042).
CONCLUSIONS
Increased liprin-α1 expression in the TILs is associated with favorable prognosis in OPSCC, especially among HPV-positive patients.
背景
Liprin-α1 是一种细胞黏附、运动和侵袭相关的支架蛋白，在恶性肿瘤中发挥作用。Liprin-α1 抑制口腔癌等癌症中转移性抑制因子 CD82 的表达，这些蛋白的表达呈负相关。这些蛋白在 HPV 相关头颈部癌症中的作用尚未被研究。我们的目的是评估 Liprin-α1 和 CD82 在 HPV 阳性口咽鳞状细胞癌（OPSCC）与 HPV 阴性 OPSCC 中的临床和预后作用。
方法
该数据纳入了 2012 年至 2016 年在赫尔辛基大学医院（HUS）治疗的 139 例 OPSCC 患者。免疫组织化学用于 HPV 检测和生物标志物检测。总体生存（OS）用于生存分析。
结果
肿瘤浸润淋巴细胞（TILs）中 Liprin-α1 表达增强与较低的癌症分期（p<0.001）和 HPV 阳性（p<0.001）相关。此外，我们发现 TILs 中 Liprin-α1 表达升高与肿瘤细胞中 CD82 表达减弱之间存在相关性（p=0.029）。在生存分析中，我们发现整个患者队列（p<0.001）和 HPV 阳性患者（p=0.042）中，TILs 中 Liprin-α1 表达增强与较好的 OS 存在显著相关性。
结论
TILs 中 Liprin-α1 表达增加与 OPSCC 的预后良好相关，尤其是在 HPV 阳性患者中。
Zotero 插件