Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China.
National Clinical Research Center for Skin and Immune Diseases, Beijing, China.
Medicine (Baltimore). 2023 May 19;102(20):e33798. doi: 10.1097/MD.0000000000033798.
Fungal urinary tract infections (UTIs) are becoming increasingly common in hospitalized patients and Candida species are the most prevalent organisms. However, recurrent candiduria in young healthy outpatients is rare thus require further examination to find the etiologic factors.
We described a case of recurrent asymptomatic c caused by azole-resistant C. glabrata in a healthy young female who only had previous use of antibiotics without other risk factors. However, after removal of the predisposing factor and the use of sensitive antifungal agents, the patient's urine cultures remained positive. This phenomenon indicated to us that the patient might have an immune-related genetic deficiency. We found a novel caspase-associated recruitment domain-containing protein 9 (CARD9) gene mutation (c.808-11G > T) which might be the cause of recurrent asymptomatic candiduria in this immune-competent young female without any underlying diseases.
We report a case of recurrent asymptomatic candiduria caused by azole-resistant Candida glabrata in a young healthy female with a novel CARD9 mutation. A functional study of this mutation should be performed in the future to determine its effect on asymptomatic fungal UTIs.
真菌性尿路感染（UTI）在住院患者中越来越常见，而念珠菌属是最常见的病原体。然而，年轻健康的门诊患者复发性假丝酵母菌尿症很少见，因此需要进一步检查以找到病因。
我们描述了一例由唑类耐药光滑念珠菌引起的复发性无症状念珠菌尿症的病例，该患者为健康年轻女性，仅使用过抗生素，无其他危险因素。然而，在去除诱发因素并使用敏感的抗真菌药物后，患者的尿液培养仍呈阳性。这一现象提示我们，患者可能存在与免疫相关的遗传缺陷。我们发现了一种新型半胱氨酸天冬氨酸蛋白酶相关募集域蛋白 9（CARD9）基因突变（c.808-11G> T），这可能是这位免疫功能正常的年轻女性无任何基础疾病但反复出现无症状假丝酵母菌尿症的原因。
我们报告了一例年轻健康女性由唑类耐药光滑念珠菌引起的复发性无症状念珠菌尿症，该患者携带一种新型 CARD9 基因突变。未来应进行该突变的功能研究，以确定其对无症状真菌性 UTI 的影响。
