Eyraud A, Lombard J Y, Descotes J, Laschi-Loquerie A, Tachon P, Veysseyre C, Evreux J C
J Antimicrob Chemother. 1986 Jun;17(6):763-6. doi: 10.1093/jac/17.6.763.
The effects of josamycin on the chemotactic response of blood polymorphonuclear leucocytes were studied. After oral administration of 2 g/day or 50 mg/kg/day for five days in man and rats respectively, polymorphonuclear chemotaxis was reduced by 20%. After in-vitro incubation with 10 mg/l josamycin chemotaxis was unaltered, whereas a 15% decrease was noted with 25 mg/l josamycin. These data suggest that josamycin is unlikely to severely impair chemotaxis in patients.
研究了交沙霉素对血液多形核白细胞趋化反应的影响。分别在人和大鼠中口服给予2g/天或50mg/kg/天，持续五天后，多形核白细胞趋化性降低了20%。在体外与10mg/l交沙霉素孵育后，趋化性未改变，而在25mg/l交沙霉素作用下，趋化性下降了15%。这些数据表明，交沙霉素不太可能严重损害患者的趋化性。
