Lombard J Y, Descotes J, Eyraud A, Evreux J C
J Pharmacol. 1986 Jul-Sep;17(3):328-30.
The chemotactic response of polymorphonuclear leukocytes using the agarose method, has been studied in six healthy volunteers, immediately prior and after a 5-day oral administration of spiramycin, 6 million units per day. The influence of spiramycin proved to be small as the directed and spontaneous migration were decreased by 21% and 18% respectively. Despite the fact that spiramycin can penetrate into leukocytes, these results indicate that no clinically relevant alterations of chemotaxis are likely under therapeutic conditions.
采用琼脂糖法对6名健康志愿者口服螺旋霉素（每天600万单位，持续5天）前后的多形核白细胞趋化反应进行了研究。结果表明，螺旋霉素的影响较小，其诱导迁移和自发迁移分别下降了21%和18%。尽管螺旋霉素能够渗透到白细胞中，但这些结果表明，在治疗条件下趋化性不太可能发生与临床相关的改变。
